Lingqiang ZHU

Personal Information

Title: Professor

Department: Department of Pathophysiology

Email: zhulq@mail.hust.edu.cn

Clinical Focus:

Research Focus/Interests: The role and mechanism of epigenetic factors, especially ncRNAs in neurodegenerative diseases

Biography

Education

09/2004-06/2007 	Ph.D. in Pathophysiology
Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
09/2002-06/2004	M.D. in Pathophysiology
Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
09/1997-06/2002 	Bachelor in Clinical Medicine
Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China

Boards, Advisory Committees, Professional Organizations

Senior Editor, Journal of Alzheimer’s Disease (IF=3.9)
Member, Chinese Neuroscience Society

Publications

1.	Zheng K, Hu F, Zhou Y, Zhang J, Zheng J, Lai C, Xiong W, Cui K, Hu Y, Han Z, Zhang H, Chen J, Man H, Liu D, Lu Y*, Zhu LQ*. MiR-135a-5p mediates memory and synaptic impairments via the Rock2/Adducin1 signaling pathway in a mouse model of Alzheimer’s disease. Nat Commun. 2021 Mar 26;12(1):1903 IF=12.353.
2.	Bao WD, Pang P, Zhou XT, Hu F, Xiong W, Chen K, Wang J, Wang F, Xie D, Hu YZ, Han ZT, Zhang HH, Wang WX, Nelson PT, Chen JG, Lu Y, Man HY, Liu D, Zhu LQ*. Loss of ferroportin induces memory impairment by promoting ferroptosis in Alzheimer’s disease. Cell Death and Differentiation. 2021;28:1548–1562. IF=10.717
3.	Bao WD, Zhou XT, Zhou LT, Wang F, Yin X, Lu Y, Zhu LQ, Liu D*. Targeting miR-124/Ferroportin signaling ameliorated neuronal cell death through inhibiting apoptosis and ferroptosis in aged intracerebral hemorrhage murine model. Aging Cell. 2020 Oct 17:e13235. IF=7.627.
4.	Chen K, Yang LN, Lai C, Liu D, Zhu LQ*. Role of Grina/Nmdara1 in the Central Nervous System Diseases. Curr Neuropharmacol. 2020;18(9):861-867. IF=4.668. 
5.	Hou TY, Zhou Y, Zhu LS, Wang X, Pang P, Wang DQ, Liuyang ZY, Man H, Lu Y, Zhu LQ*, Liu D*. Correcting abnormalities in miR-124/PTPN1 signaling rescues taupathology in Alzheimer's disease. J Neurochem. 2020 Aug;154(4):441-457.  IF=4.870.
6.	Ma M, Xiong W, Hu F, Deng MF, Huang X, Chen JG, Man HY, Lu Y*, Liu D*, Zhu LQ*. A novel pathway regulates social hierarchy via lncRNA AtLAS and postsynaptic synapsin IIb. Cell Res. 2020 Feb;30(2):105-118. IF=20.2.
7.	Gilbert J, O'Connor M, Templet S, Moghaddam M, Di Via Ioschpe A, Sinclair A, Zhu LQ, Xu W, Man HY*. NEXMIF/KIDLIA knockout mouse demonstrates autism-likebehaviors, memory deficits, and impairments in synapse formation and function. J Neurosci. 2020 Jan 2;40(1):237-254. IF=6.074.
8.	Zhou XT, Bao WD, Liu D, Zhu LQ*. Targeting the neuronal activity of prefrontal cortex: new directions for the therapy of depression. Curr Neuropharmacol. 2019 Nov 1. IF=4.568.
9.	Zhou YF, Wang J, Deng MF, Chi B, Wei N, Chen JG, Liu D, Yin X*, Lu Y*, Zhu LQ*. The Peptide-Directed Lysosomal Degradation of CDK5 Exerts Therapeutic Effects against Stroke. Aging Dis. 2019 Oct 1;10(5):1140-1145. IF=4.232.
10.	Ouyang Y, Li D, Wang H, Wan Z, Luo Q, Zhong Y, Yin M, Qing Z, Li Z, Bao B, Chen Z, Yin X*, Zhu LQ*. MiR-21-5p/dual-specificity phosphatase 8 signalling mediates the anti-inflammatory effect of haem oxygenase-1 in aged intracerebral haemorrhage rats. Aging Cell. 2019 Dec;18(6):e13022. IF=7.627.
11.	Zhu LS, Wang DQ, Cui K, Liu D, Zhu LQ*. Emerging Perspectives on DNA double-strand breaks in Neurodegenerative Diseases. Curr Neuropharmacol. 2019 17(12):1146-1157. IF=4.568. 
12.	Xie AJ, Hou TY, Xiong W, Huang HZ, Zheng J, Li K, Man HY, Hu YZ, Han ZT, Zhang HH, Wei N, Wang JZ*, Liu D, Lu Y*, Zhu LQ*. Tau overexpression impairs neuronal endocytosis by decreasing the GTPase dynamin 1 through the miR-132/MeCP2 pathway. Aging Cell. 2019 Jun;18(3):e12929. IF=7.627.
13.	Tang H, Ma M, Wu Y, Deng MF, Hu F, Almansoub H, Huang HZ, Wang DQ, Zhou LT, Wei N, Man HY, Lu Y, Liu D*, Zhu LQ*. Activation of MT2 receptor ameliorates dendritic abnormalities in Alzheimer’s disease via C/EBPα/miR-125b pathway. Aging Cell. 2019 Apr; 18(2):e12902. IF=7.627.
14.	Su Y, Deng MF, Xiong W, Xie AJ, Guo J, Liang ZH, Hu B, Chen JG, Man HY, Lu Y, Liu D, Tang B*, Zhu LQ*. MicroRNA-26a/Death-associated protein kinase 1 signaling induces synucleinopathy and dopaminergic neuron degeneration in Parkinson’s disease. Biol Psychiatry. 2019;85(9):769-781. IF=11.982.
15.	Li X, Chen W, Pan K, Li H, Pang P, Guo Y, Shu S, Cai Y, Pei L, Liu D, Afewerky HK, Tian Q, Zhu LQ*, Lu Y*. Serotonin receptor 2c-expressing cells in the ventral CA1 control attention via innervation of the Edinger-Westphal nucleus. Nat Neurosci. 2018 Sep;21(9):1239-1250. IF=21.136.
16.	Li K, Wei Q, Liu FF, Hu F, Xie AJ, Zhu LQ*, Liu D*. Synaptic Dysfunction in Alzheimer's Disease: Aβ, Tau, and Epigenetic Alterations. Mol Neurobiol. 2018 55:3021-3032. IF=5.076.
17.	Wang X, Liu D, Huang HZ, Wang ZH, Hou TY, Yang X, Pang P, Wei N, Zhou YF, Dupras MJ, Calon F, Wang YT, Man HY, Chen JG, Wang JZ, Hébert SS, Lu Y, Zhu LQ*. A Novel MicroRNA-124/PTPN1 Signal Pathway Mediates Synaptic and Memory Deficits in Alzheimer's Disease. Biol Psychiatry. 2018:83;395-405. (Highlight in this issue and commentary by Dr. Wang-Xia Wang) IF=11.982.
18.	Yang X, Yao C, Tian T, Li X, Yan H, Wu J, Li H, Pei L, Liu D, Tian Q, Zhu LQ*, Lu Y*. Synaptic mechanism in Alzheimer's disease: a selective degeneration of an excitatory synaptic pathway in the CA1 hippocampus that controls spatial learning and memory in Alzheimer's disease. Mol Psychiatry. 2018 Feb;23(2):167. IF=11.640.
19.	Yang X, Yao C, Tian T, Li X, Yan H, Wu J, Li H, Pei L, Liu D, Tian Q, Zhu LQ*, Lu Y*. A novel mechanism of a memory loss in Alzheimer’s disease mice via degeneration of entorhinal-CA1 synapses. Mol Psychiatry. 2018: 23(2):199-210. IF=11.640.
20.	Wang DQ, Fu P, Yao C, Zhu LS, Hou TY, Chen JG, Lu Y, Liu D*, Zhu LQ*. Long non-coding RNAs, novel culprits or bodyguards in neu-rodegenerative diseases. Molecular Therapy-Nucleic Acid. 2018, 10(2):269-276. IF=5.660.
21.	Zhu H, Yan H, Tang N, Li X, Pang P, Li H, Chen W, Guo Y, Shu S, Cai Y, Pei L, Liu D, Luo MH, Man H, Tian Q, Mu Y*, Zhu LQ*, Lu Y*. Impairments of spatial memory in an Alzheimer’s disease model via degeneration of hippocampal cholinergic synapses. Nat Commun. 2017 Nov 22;8(1):1676. IF=12.353.
22.	Yang S, Jin H, Zhu Y, Wan Y, Opuku EN, Zhu LQ*, Hu B*. Diverse Functions and Mechanisms of Pericytes in Ischemic Stroke. Current Neuropharmacology, 2017;15(6):892-905. IF=4.068.
23.	Liu D, Tang H, Li XY, Deng MF, Wei N, Wang X, Zhou YF, Wang DQ, Fu P, Wang JZ, Hebert SS, Chen JG, Lu Y, Zhu LQ*. Targeting the HDAC2/HNF-4A/miR0101b/AMPK pathway rescues tauopathy and dendritic abnormalities in Alzheimer’s disease Molecular Therapy. 2017 Mar 1;25(3):752-764.  IF=7.008.
24.	An TH, He QW, Xia YP, Chen SC, Baral S, Mao L, Jin HJ, Li YN, Wang MD, Chen JG, Zhu LQ*, Hu B*. MiR-181b Antagonizes Atherosclerotic Plaque Vulnerability Through Modulating Macrophage Polarization by Directly Targeting Notch1. Mol Neurobiol. 2017 Oct;54(8):6329-6341. IF=5.076.
25.	Liu YS, Dai X, Wu W, Yuan FF, Gu X, Chen JG, Zhu LQ*, Wu J*. The Association of SNAP25 Gene Polymorphisms in Attention Deficit/Hyperactivity Disorder: a Systematic Review and Meta-Analysis. Mol Neurobiol. 2017 Apr;54(3):2189-2200. IF=5.076.
26.	Shu S, Zhu HZ, Tang N, Chen W, Li X, Li H, Pei L, Liu D, Mu Y, Tian Q, Zhu LQ*, Lu Y*. Selective Degeneration of Entorhinal-CA1 Synapses in Alzheimer’s Disease via Activation of DAPK1. J Neurosci. 2016 Oct 19;36(42):10843-10852. IF=5.970.
27.	Xie AJ, Liu EJ, Huang HZ, Hu Y, Li K, Lu Y, Wang JZ*, Zhu LQ*. Cnga2 Knockout Mice Display Alzheimer's-Like Behavior Abnormities and Pathological Changes. Mol Neurobiol. 53(7), 4992-4999. IF=5.076.
28.	Xiong YS, Liu FF, Liu D, Huang HZ, Wei N, Tan L, Chen JG, Man HY, Gong CX, Lu Y, Wang JZ, Zhu LQ*. Opposite effects of two estrogen receptors on tau phosphorylation regulation through disparate effects on the miR-218/PTPA pathway. Aging Cell, 2015, 14: 867–877. IF=7.627.
29.	Wang MD, Wang Y, Xia YP, Dai JW, Gao L, Wang SQ, Wang HJ, Mao L, Li M, Yu SM, Tu Y, He QW, Zhang GP, Wang L, Xu GZ, Xu HB, Zhu LQ*, Hu B*. High Serum MiR-130a Levels Are Associated with Severe Perihematomal Edema and Predict Adverse Outcome in Acute ICH. Mol Neurobiol. 2016 Mar;53(2):1310-21. IF=5.076.
30.	Li K, Liu FF, He CX, Huang HZ, Xie AJ, Hu F, Liu D, Wang JZ*, Zhu LQ*. Olfactory Deprivation Hastens Alzheimer-Like Pathologies in a Human Tau-Overexpressed Mouse Model via Activation of cdk5. Mol Neurobiol. 2016 Jan;53(1):391-401. IF=5.076.
31.	Liu D, Wei N, Man HY, Lu Y, Wang JZ, Zhu LQ*. The MT2 receptor stimulates axonogenesis and enhances synaptic transmission by activating Akt signaling. Cell Death & Differentiation. 2015 Apr;22(4):583-96. IF=8.000.
32.	Hu J, Huang HZ, Wang X, Xie AJ, Wang X, Liu D, Wang JZ, Zhu LQ*. Glycogen synthase kinase-3 links the olfactory deficit to hippocampal impairments. Mol Neurobiol. 2015 Dec;52(3):1601-17. IF=5.076.
33.	Liu DY, Shen XM, Yuan FF, Guo OY, Zhong Y, Chen JG, Zhu LQ* Wu J. The physiology of BDNF and its relationship with ADHD. Mol Neurobiol. 2015 Dec;52(3):1467-1476. IF=5.076.
34.	Pei L, Shang Y, Jin H, Wang S, Wei N, Yan H, Wu Y, Yao C, Wang X, Zhu LQ*, Lu Y*. DAPK1-p53 Interaction Converges Necrotic and Apoptotic Pathways of Ischemic Neuronal Death. J Neurosci. 2014 May 7;34(19):6546-56. IF=5.970.
35.	Wang X, Wang LP, Tang H, Shan WY, Wang X, Liu D, Wu YY, Tian Q, Wang JZ*, Zhu LQ*. Acetyl-l-carnitine rescues scopolamine-induced memory deficits by restoring insulin-like growth factor II via decreasing p53 oxidation. Neuropharmacology. 2014, 76(A) :80-87. IF=4.249.
36.	Wu YY, Wang X, Tan L, Liu D, Liu XH, Wang Q, Wang JZ*, Zhu LQ*. Lithium Attenuates Scopolamine-Induced Memory Deficits with Inhibition of GSK-3β and Preservation of Postsynaptic Components. J Alzheimers Dis. 2013, 37(3):515-527. IF=3.476.
37.	Tang H, Shen N, Jin HJ, Liu D*, Miao X*, Zhu LQ*. GSK-3β polymorphism discriminates bipolar disorder and schizophrenia: a systematic meta-analysis. Molecular Neurobiology. 2013,48(3):404-411. IF=5.076.
38.	Xiong YS, Wang DL, Tan L, Wang X, Chen LM, Gong CX, Wang JZ*, Zhu LQ*. Inhibiton of glycogen synthase kinase-3 reverses tau hyperphosphorylation induced by Pin1 downregulation. CNS & Neurological Disorders - Drug Targets. 2013, 12(3):436-443. IF=2.084.
39.	Zhao K, Wen R, Wang X, Pei L, Yang Y, Shang Y, Bazan N, Zhu LQ*, Tian Q*, Lu Y*. EPAC Inhibition of SUR1 Receptor Increases Glutamate Release and Seizure Vulnerability. J Neurosci. 2013,33(20):8861-8865. IF=5.970.
40.	Peng CX, Hu J, Liu D, Hong XP, Wu YY, Zhu LQ*, Wang JZ*. Disease-modified GSK-3 intervention by melatonin arrests the pathology and memory deficits in Alzheimer’s animal model. Neurobiology of Aging. 2013, 34(6):1555-1563. IF=4.454.
41.	Qu M, Jiang J, Liu XP, Tian Q, Chen LM, Yin G, Liu D, Wang JZ*, Zhu LQ*. Reduction and the intracellular translocation of EphB2 in Tg2576 mice and the effects of -amyloid. Neuropathology and Applied Neurobiology. 2013 Oct;39(6):612-22. IF=6.059.
42.	Zhong R, Yang B, Tang H, Zou L, Song R, Zhu LQ*, Miao XP*. Meta-analysis of the association between DCDC2 polymorphisms and risk of Dyslexia. Molecular Neurobiology. 2013;47(1):435-442. IF=5.076.
43.	Wang X, Wang ZH, Wu YY, Tang H, Tan L, Wang X, Gao XY, Xiong YS, Liu D*, Wang JZ, Zhu LQ*. Melatonin attenuates scopolamine-induced memory/synaptic disorder by rescuing EPACs/miR-124/Egr1 pathsway. Molecular Neurobiology. 2013;47(1):373-381. IF=5.076.
44.	Wang SH, Liao XM, Liu D, Hu J, Yin YY, Wang JZ*, Zhu LQ*. NGF Promotes Long-term Memory Formation by Activating Poly(ADP-ribose)polymerase-1. Neuropharmacology. 2012;63(6):1085-1092 IF=4.249.
45.	Wu J, Xiao H, Sun H, Zou L, Zhu LQ*. Role of dopamine receprots in ADHD: a systematic meta-analysis. Molecular Neurobiology. 2012; 45(3):605-20. IF=5.076.
46.	Yang Y, Shu X, Liu D, Shang Y, Wu Y, Pei L, Xu X, Tian Q, Zhang J, Qian K, Wang YX, Petralia RS, Tu WH, Zhu LQ*, Wang JZ*, Lu Y*. EPAC Null Mutation Impairs Learning and Social Interactions via Aberrant Regulation of miR-124 and Zif268 Translation. Neuron, 2012;73(4):774-788. IF=14.318. 
47.	Liao K, Liu D, Zhu LQ*. Enriched odor exposure decrease tau phosphorylation in the rat hippocampus and cortex. Neurosci Lett. 2012;507(1):22-26. IF=2.159.
48.	Hu J, Wang X, Liu D, Wang Q, Zhu LQ*. Olfactory deficits induce neurofilament hyperphosphorylation. Neurosci Lett. 2012; 506(2):180-183. IF=2.159.
49.	Zhou P, Chen Z, Zhao N, Liu D, Hu J, Guo ZY, Wang Q, Wang JZ*, Zhu LQ*. Acetyl-L-Carnitine attenuates homocysteine-induced Alzheimer-like histopathological and behavioral abnormalities. Rejuvenation Research. 2011, 14(6): 669-679. IF=3.220.
50.	Jiang X, Tian Q, Wang Y, Zhou XW, Xie JZ, Wang JZ, Zhu LQ*. Acetyl-L-Carnitine ameliorates spatial memory deficits induced by inhibition of phosphoinositol-3 kinase and protein kinase C. J Neurochem. 2011;118(5):864-878. IF=4.609.
51.	Chen LM, Xiong YS, Kong FL, Qu M, Wang Q, Chen XQ, Wang JZ*, Zhu LQ*. Neuroglobin attenuates Alzheimer-like tau hyperphosphorylation by activating Akt signaling. J Neurochem. 2012 Jan;120(1):157-64. IF=4.609.
52.	Liu D, Zheng HY, Luo ZZ, Wang Q, Zhu LQ*. Effect of PP-2A on neurite outgrowth in neuronal cells. In Vitro Cell Dev-AN, 2010, 46(8): 702-707 IF=1.447.
53.	Zhu LQ#, Liu D#, Hu J, Cheng J, Wang SH, Wang Q, Wang F, Chen JG, Wang JZ. GSK-3 inhibits presynaptic vesicle exocytosis by phosphorylating P/Q-type calcium channel and interrupting SNARE complex formation. J Neurosci. 2010;30(10):3624-33. IF=5.970.
54.	Zhu LQ#, Zheng HY#, Peng CX, Liu D, Li HL, Wang Q, Wang JZ. Protein phosphatase 2A facilitates functional axonogenesis by dephosphorylating CRMP2. J Neurosci. 2010;30(10):3839-48. IF=5.970.
55.	Yin YY, Liu H, Liu Z, Cong XB, Wang Q, Wang JZ*, Zhu LQ*. Acetyl-L-carnitine attenuates okadaic acid induced tau hyperphosphorylation and spatial memory impairment in rats. J Alzheimer’s Disease 2010;19(2):735-46. IF=3.476.
56.	Shi HR#, Zhu LQ#, Wang SH, Liu XA, Tian Q, Zhang Q, Wang Q, Wang JZ*. (2008). 17 β-estradiol attnuates glycogen synthase kinase-3β activation and tau hyperphosphorylation in Akt-independent manner. J Neural Transmission 115(6):879-888. IF=2.776.
57.	Liu XA#, Zhu LQ#, Zhang Q, Shi HR, Wang SH, Wang Q, Wang JZ*. (2008). Estradiol attenuates tau hyperphosphorylation induced by upregulation of protein kinase-A. Neurochemical Res 2008 Sep;33(9):1811-20. IF=2.772.
58.	Zhu LQ#, Wang SH#, Liu D, Yin YY, Tian Q, Wang XC, Wang Q, Chen JG, Wang JZ (2007). Activation of glycogen synthase kinase-3 inhibits long term potentiation with synapse-associated impairments. J Neurosci 27:12211-12220. IF=5.970. 
59.	Wang SH#, Zhu LQ#, Wang Q, et al. (2007). Inhibition of Melatonin Biosynthesis Induces Neurofilament Hyperphosphorylation with Activation of Cyclin-dependent Kinase 5. Neurochem Res 32(8):1329-1335. IF=2.772.
60.	Zhu LQ#, Wang SH, Ling ZQ, et al. 2005. Inhibition of melatonin biosynthesis activates protein kinase A and Alzheimer-like tau hyperphosphorylation in rat. Chinese Medical Science J 20(2):83-87. 
61.	Zhu LQ#, Wang SH, Ling ZQ, et al. (2004). Effect of inhibiting melatonin biosynthesis on    spatial memory retention and tau phosphorylation in rat. J Pineal Res 37 (2):71-77. IF=11.613.

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Lingqiang ZHU

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