Jun ZHAO

Personal Information

Title: Professor

Department: Department of Anatomy

Email: 2037322108@qq.com

Clinical Focus:

Research Focus/Interests:

Biography

Positions and Employment:
2019-Present   Professor, School of Basic Medicine, Huazhong University of Science and Technology, Wuhan, Hubei Province, China
2015-2019   Instructor, Department of Cancer Systems Imaging, University of Texas MD Anderson Cancer Center, Houston, TX
2009-2015   Postdoctoral Fellow, University of Texas MD Anderson Cancer Center, Houston, TX. (Supervisor: Dr. Chun Li)

Honors:
2009	Ronald Dollens Graduate Scholarship, Purdue University
2006	Graduate Fellowship, Indiana University Purdue University-Indianapolis
2002	Outstanding Student Award, University of Science and Technology of China
1999	First Grade Fellowship sponsored by Huawei Technologies Co., Ltd

Invited Talks:
1.	Zhao J., Wu C., Li J., Hwang R.,Li C. “Cyclopamine-loaded Core-crosslinked Polymeric Micelles Enhanced Radiation Response in Pancreatic Cancer”. 10th International Symposium on Polymer Therapeutics: From Laboratory to Clinical Practice, Valencia, Spain, 5/2014
2.	Zhao J., Tam A., Melancon M., McWatters A., Gupta S., Li C. “Electroporation Induced Delivery of siRNA-loaded Copper Sulfide Nanoparticles”. Society of Interventional Radiology Annual Scientific Meeting, New Orleans, 2013
3.	Zhao J., Vykoukal J., Abdelsalam M., Javadi S., Bankson J., Wallace M., Avritscher R., Melancon M. “Adipose-derived Stem Cells Labeled with SPIO-loaded Hollow Gold Nanoshells as Theranostic Approach for Liver Injury”. Society of Interventional Radiology Annual Scientific Meeting, New Orleans, 2013

Education

09/2004   B.S. in Chemistry, University of Science and Technology of China, Hefei, China
07/2006	  M.S.	in Biomedical Engineering, Indiana University Purdue University-Indianapolis, IN
12/2009   Ph.D. in Biomedical Engineering, Purdue University-West Lafayette, IN

Boards, Advisory Committees, Professional Organizations

Member, American Chemical Society (2007-present)
Reviewer, Advanced Functional Materials, Small, Acta Biomaterialia, Nanomedicine, etc.

Publications

1.	Lincha, V. R.†; Zhao, J.†; Wen, X.; Xiong, C.; D, S. L. Chow; and Li, C., A polymeric micellar drug delivery system developed through a Design of Experiment approach improves pancreatic tumor accumulation of calcipotriol and paclitaxel. International Journal Pharmaceutics, 2021: p. 120523（IF 4.845）
2.	Bao, G.; Tang, M.; Zhao, J.*; and Zhu, X.*, Nanobody: a promising toolkit for molecular imaging and disease therapy. EJNMMI Res, 2021. 11(1): p. 6. DOI: 10.1186/s13550-021-00750-5（IF 2.640）
3.	Wu, Z. L.†; Zhao, J.†; and Xu, R., Recent advances in oral nano-antibiotics for bacterial infection therapy. Interntional Journal of Nanomedicine, 2020. 15: p. 9587-9610（IF 5.115）
4.	Zhao, J.†; Wen, X.†; Li, T.; Shi, S.; Xiong, C.; Wang, Y. A.; and Li, C., Concurrent Injection of Unlabeled Antibodies Allows Positron Emission Tomography Imaging of Programmed Cell Death Ligand 1 Expression in an Orthotopic Pancreatic Tumor Model. ACS Omega, 2020. 5(15): p. 8474-8482. (IF 2.87)
5.	He, J. †; Qiao, Y. †; Zhang H. †; Zhao, J. †; Li, W.; Xie, T.; Zhong, D.; Wei, Q.; Hua, S.; Yu, Y.; Yao, K.; Santos, H.; Zhou M. Gold–silver nanoshells promote wound healing from drug-resistant bacteria infection and enable monitoring via surface-enhanced Raman scattering imaging. Biomaterials 2020, 234, 119763. (IF 10.274)
6.	Zhong, D. †; Zhao, J. †; Li, Y; Qiao, Y.; Wei, Q.; He, J.; Xie, T.; Li, W., Zhou, M. Laser-triggered aggregated cubic α-Fe2O3@Au nanocomposites for magnetic resonance imaging and photothermal/enhanced radiation synergistic therapy. Biomaterials 2019, 210, 119369. (IF 10.274)
7.	Zhao, J.†; Wen, X. F.†; Tian, L.; Li, T.; Xu, C.; Wen, X. X.; Melancon, M. P., Gupta, S.; Shen, B.; Peng, W.; Li, C. Irreversible electroporation reverses resistance to immune checkpoint blockade in pancreatic cancer. Nature Communications 2019, 10:899. (IF 11.880)
8.	Zhao, J.; Xiao, Z.; Li, T.; Chen, H.; Yuan, Y.; Wang, A. Y.; Hsiao, C. -H.; Chow, D. S.-L.; Overwijk, W.; Li, C. Stromal modulation reverses primary resistance to immune checkpoint blockade in pancreatic cancer. ACS Nano 2018, 12, 9881-9893. (IF 13.709)
9.	Zhou, B.†; Zhao, J.†; Qiao, Y.; Wei, Q.; He, J.; Li, W.; Zhong, D.; Ma, F.; Li, Y.; Zhou, M. Simultaneous multimodal imaging and photothermal therapy via renal-clearable manganese-doped copper sulfide nanodots. Applied Materials Today 2018, 13, 285-297. (IF 8.013)
10.	Zhao, J.; Wang, H.; Hsiao, C.-H.; Chow, D. S.-L.; Koay, E. J.; Kang, Y.; Wen, X.; Huang, Q.; Ma, Y.; Bankson, J. A.; et al. Simultaneous inhibition of hedgehog signaling and tumor proliferation remodels stroma and enhances pancreatic cancer therapy. Biomaterials 2018, 159, 215-228. (IF 10.273)
11.	Zhao, J.; Koay, E. J.; Li, T.; Wen, X.; Li, C., A hindsight reflection on the clinical studies of poly (l‐glutamic acid)‐paclitaxel. Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology 2018, 10 (3), e1497. (IF 6.35)
12.	Wang, W.†; Zhao, J.†; Wen, X.; Lin, C. C.-J.; Li, J.; Huang, Q.; Yu, Y.; Lin, S.-Y.; Li, C., MicroPET/CT Imaging of AXL Downregulation by HSP90 Inhibition in Triple-Negative Breast Cancer. Contrast Media & Molecular Imaging 2017, 2017. (IF 2.934)
13.	Zhao, J.; Zhou, M.; Li, C., Synthetic nanoparticles for delivery of radioisotopes and radiosensitizers in cancer therapy. Cancer Nanotechnology 2016, 7 (9). (IF 4.22）
14.	Zhou, M.; Zhao, J.; Tian, M.; Song, S.; Zhang, R.; Gupta, S.; Tan, D.; Shen, H.; Ferrari, M.; Li, C., Radio-photothermal therapy mediated by a single compartment nanoplatform depletes tumor initiating cells and reduces lung metastasis in the orthotopic 4T1 breast tumor model. Nanoscale 2015, 7 (46), 19438-19447. (F 7.233)
15.	Zhou, M.; Song, S.; Zhao, J.; Tian, M.; Li, C., Theranostic CuS nanoparticles targeting folate receptors for PET image-guided photothermal therapy. Journal of Materials Chemistry B 2015, 3 (46), 8939-8948. (IF 4.534) 
16.	Zhao, J.; Wu, C.; Abbruzzese, J.; Hwang, R. F.; Li, C., Cyclopamine-loaded core-cross-linked polymeric micelles enhance radiation response in pancreatic cancer and pancreatic stellate cells. Molecular Pharmaceutics 2015, 12 (6), 2093-2100.  (IF 4.556)
17.	Zhao, J.; Qiao, Y.; Zhou, M.; Wallace, M.; Gupta, S.; Li, C.; Melancon, M. P., Antitumor Efficacy of Irreversible Electroporation and Doxorubicin-Loaded Polymeric Micelles. ACS Macro Letters 2015, 4 (10), 1081-1084. (IF 6.131)
18.	Zhao, J.; Lee, P.; J Wallace, M.; P Melancon, M., Gold nanoparticles in cancer therapy: efficacy, Biodistribution, and Toxicity. Current Pharmaceutical Design 2015, 21 (29), 4240-4251. (IF 2.757)
19.	You, J.†; Zhao, J.†; Wen, X.; Wu, C.; Huang, Q.; Guan, F.; Wu, R.; Liang, D.; Li, C., Chemoradiation therapy using cyclopamine-loaded liquid–lipid nanoparticles and lutetium-177-labeled core-crosslinked polymeric micelles. Journal of Controlled Release 2015, 202, 40-48. (IF 7.877)
20.	Zhao, J.; Wallace, M.; Melancon, M. P., Cancer theranostics with gold nanoshells. Nanomedicine 2014, 9 (13), 2041-2057. (IF 5.005)
21.	Zhao, J.; Vykoukal, J.; Abdelsalam, M.; Recio-Boiles, A.; Huang, Q.; Qiao, Y.; Singhana, B.; Wallace, M.; Avritscher, R.; Melancon, M. P., Stem cell-mediated delivery of SPIO-loaded gold nanoparticles for the theranosis of liver injury and hepatocellular carcinoma. Nanotechnology 2014, 25 (40), 405101. (IF 3.404)
22.	 Zhao, J.†; Song, S.†; Zhong, M.; Li, C., Dual-Modal Tumor Imaging via Long-Circulating Biodegradable Core-Cross-Linked Polymeric Micelles. ACS Macro Letters 2011, 1 (1), 150-153. (IF 6.131)

Patents:
1.	Chun Li, Jun Zhao, Jason Fleming. Polymeric Drug Delivery Systems for Treatment of Disease, United States, 62/265,167, Pending

Funding Supports:
1.	Nanoparticle-mediated Controlled Drug Release to Modulate Tumor-Associated Neutrophils and Enhance the Response of Pancreatic Cancer to Combined Irreversible Electroporation and Anti-PD1 Therapy, National Natural Science Foundation of China 82073400, 2021.01-2024.12, ￥550,000, Principal Investigator.
2.	Improve Radiation Efficacy in Pancreatic Tumor using Nanoparticle-bound Radiosensitizer，MD Anderson Cancer Center，4/1/2016-3/31/2017, $30,000，Principal Investigator.
3.	Determination of the efficacy of TIG1-targeted therapy using nanoparticle-delivered siRNA in inflammatory breast cancer, Morgan Welch Inflammatory Breast Cancer Research Program, 4/1/2016-3/31/2017, $40,000，Co-Principal Investigator.
4.	Targeted Delivery of Cyclopamine by Biodegradable Cross-Linked Polymeric Micelles for Radio-Chemotherapy of Pancreatic Cancer，Skip Viragh Foundation，2012-2018，$1,400,000，Collaborator.
5.	Simultaneous Ablation of Tumor Cells and Tumor Stromal Cells to Enhance Antitumor against Pancreatic Ductal Adenocarcinoma，Gillson Longenbaugh Foundation，2016-2018，$80,000，Collaborator

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Jun ZHAO

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