Hongjun YU

Personal Information

Title: Professor

Department: Department of Biochemistry and Molecular Biology

Email: hongjun_yu@hust.edu.cn

Clinical Focus:

Research Focus/Interests: to use multiple methods such as cryoEM, X-ray crystallography, Biochemistry and Cell biology to explore the structures and functions of macromolecules related to human diseases

Biography

2018-present      Professor
Department of Biochemistry and Molecular Biology, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
2016-2018         Research Scientist
Van Andel Research Institute, Michigan, USA
2011-2016         Research Associate
Brookhaven National Laboratory, New York, USA

Education

Ph.D. in Biochemistry and Molecular Biology, 2011, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China
BS in Biophysics, 2005, Nankai University, Tianjin, China

Boards, Advisory Committees, Professional Organizations

Publications

1.	Yu HJ, Wu CH, Schut G, Haja D, Zhao G, Peters J, Adams M# and Li H#. Structure of an Ancient Respiratory System. Cell, 2018. 173(7):1636-1649.e16.
2.	Yu HJ＊, Takeuchi H.＊, Takeuchi M., Liu Q., Kantharia J., Haltiwanger RS.#, Li H#. Structural analysis of Notch-regulating Rumi reveals basis for pathogenic mutations. Nature Chemical Biology, 2016, 12(9):735-40.
3.	Yu HJ, Takeuchi M, LeBarron J, Kantharia J, London E, Bakker H, Haltiwanger RS, Li H#, Takeuchi H#. Notch-modifying xylosyltransferase structures support an SNi-like retaining mechanism. Nature Chemical Biology, 2015, 11(11):847-54.
4.	Yu HJ, Lupoli T, Kovach A, Meng X, Zhao G, Nathan C# and Li H#. ATP hydrolysis-coupled peptide translocation mechanism of Mycobacterium tuberculosis ClpB. PNAS, 2018 Oct 9;115(41):E9560-E9569.
5.	Yu HJ*, Haja D*, Schut G, Wu CH, Meng X, Zhao GP, Li HL, Adams M. Structure of the respiratory MBS complex reveals iron-sulfur cluster catalyzed sulfane sulfur reduction in ancient life. Nature Commun. 2020 Nov 23;11(1):5953.
6.	Yu HJ, Takeuchi H. Protein O-glucosylation: another essential role of glucose in biology. Curr Opin Struct Biol. 2019 Jan 18;56:64-71.
7.	Yu HJ#, Schut GJ, Haja DK, Adams MWW#, Li H#. Evolution of complex I-like respiratory complexes. J Biol Chem. 2021, 3;296:100740. （#Corresponding author）
8.	Takeuchi H*, Yu HJ*, Hao HL, Takeuchi M, Ito A, Li H & Robert H#. O-Glycosylation modulates the stability of epidermal growth factor-like repeats and thereby regulates Notch trafficking. J Biol Chem. 2017, 292(38): 15964–15973. （*Equal contribution）
9.	Yin Y*, Feng X*, Yu H*, Fay A, Kovach A, Glickman MS, Li H. Structural basis for aggregate dissolution and refolding by the Mycobacterium tuberculosis ClpB-DnaK bi-chaperone system. Cell Rep. 2021, 25;35(8):109166. （*Equal contribution）
10.	Du M, Yuan Z, Yu HJ, Henderson N, Sarowar S, Zhao G, Werneburg G, Thanassi D, Li H#. Handover of chaperone-subunit complexes during pilus assembly by the outer membrane usher. Nature, 2018 Oct;562(7727):444-447.
11.	Gong Y*, Cao P＊, Yu HJ, Jiang T#. Crystal structure of the neurotrophin-3 and p75NTR symmetrical complex. Nature, 2008, 454, 789-793.

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Hongjun YU

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