Xiaochuan Wang

Personal Information

Title: Professor
Department: Department of Pathophysiology
Email:
Clinical Focus:
Research Focus/Interests: 1. Alzheimer disease pathogenesis and prevention; 2. the pathogenesis of brain aging.
Biography

Education

Boards, Advisory Committees, Professional Organizations

Publications

1. Xia Y, Wang ZH, Liu P, Edgington-Mitchell L, Liu X, Wang XC*, Ye K. TrkB receptor cleavage by delta-secretase abolishes its phosphorylation of APP, aggravating Alzheimer's disease pathologies. Mol Psychiatry. 2020 Aug 11. doi: 10.1038/s41380-020-00863-8. Online ahead of print.

2. Xu J, Guo C, Liu Y, Wu G, Ke D, Wang Q, Mao J, Wang JZ, Liu R, Wang XC*. Nedd4l downregulation of NRG1 in the mPFC induces depression-like behaviour in CSDS mice. Transl Psychiatry. 2020 Jul 23;10(1):249. doi: 10.1038/s41398-020-00935-x.

3. Guo C, Liu Y, Fang M, Li Y, Li W, Mahaman YAR, Zeng K, Xia Y, Ke D, Liu R, Wang JZ, Shen H, Shu X, Wang XC*. ω-3PUFAs improves cognitive impairments through Ser133 phosphorylation of CREB up-regulating BDNF/TrkB signal in schizophrenia. Neurotherapeutics, 2020. May 4. doi: 10.1007/s13311-020-00859-w. Online ahead of print.

4. Wan L, Zhang Q, Luo H, Xu Z, Huang S, Yang F, Liu Y, Mahaman YAR, Ke D, Wang Q, Liu R, Wang JZ, Shu X, Wang XC*. Codonopsis pilosula Polysaccharide attenuates Aβ toxicity and cognitive defects in APP/PS1 mice. Aging, 2020 Jul 11;12(13):13422-13436. doi: 10.18632/aging.103445.

5. Huang F, Wang M, Liu R, Wang JZ, Schadt E, Haroutunian V, Katsel P, Zhang B, Wang XC*. CDT2 Controlled Cell Cycle Reentry Regulates the Pathogenesis of Alzheimer’s Disease. Alzheimers & Dementia. 2019 Feb;15(2):217-231. doi: 10.1016/j.jalz.2018.08.013. Epub 2018 Oct 12.

6. Mahaman YAR, Huang F, Henok KA, Maibouge TMS, Ghose B, Wang XC*. Involvement of calpain in the neuropathogenesis of Alzheimer’s Disease. Medicinal Research Reviews. 2019 Mar;39(2):608-630. doi: 10.1002/med.21534.

7. Qin M, Li H, Bao J, Xia Y, Ke D, Wang Q, Liu R, Wang JZ, Zhang B, Shu X, Wang XC*. SET SUMOylation promotes its cytoplasmic retention and induces tau pathology and cognitiveimpairments. Acta Neuropathol Commun. 2019 Feb 15;7(1):21. doi: 10.1186/s40478-019-0663-0.

8. Wei Z, Mahaman YAR, Zhu F, Wu M, Xia Y, Zeng K, Yang Y, Liu R, Wang JZ, Shu X, Wang XC*. GSK-3β and ERK1/2 incongruously act in tau hyperphosphorylation in SPS-induced PTSD rats. Aging (Albany NY). 2019 Sep 23;11(18):7978-7995. doi: 10.18632/aging.102303. Epub 2019 Sep 23.

9. Li X, Run X, Wei Z, Zeng K, Liang Z, Huang F, Ke D, Wang Q, Wang JZ, Liu R, Zhang B, Wang XC*. Intranasal insulin prevents anesthesia-induced cognitive impairments in aged mice. Curr Alzheimer Res. 2019;16(1):8-18. doi: 10.2174/1567205015666181031145045.

10. Zhang Q, Xia Y, Wang Y, Luo H, Huang S, Wang Y, Shentu Y, Mahaman YAR, Huang F, Wu M, Ke D, Wang Q, Liu R, Wang JZ, Zhang B, Wang XC*. Codonopsis pilosula Polysaccharide attenuates tau hyperphosphorylation and cognitive impairments in hTau infected mice. Front Mol Neurosci. 2018 Nov 27;11:437. doi: 10.3389/fnmol.2018.00437. eCollection 2018.

11. Maibouge TMS, Mahaman YAR, Zhu F, Huang F, Wang Y, Xu Z, Ke D, Wang Q, Liu R, Wang JZ, Zhang B, Wang XC* Methanolic extract of Tamarix Gallica attenuates hyperhomocysteinemia induced AD-like pathology and cognitive impairments in rats. Aging (Albany NY). 2018 Nov 12;10(11):3229-3248. doi: 10.18632/aging.101627.

12. Wu M, Yu G, Yan T, Ke D, Wang Q, Liu R, Wang JZ, Zhang B, Chen D, Wang XC*. Phosphorylation of SET mediates apoptosis via P53 hyperactivation and NM23-H1 nuclear import. Neurobiol Aging. 2018 Sep;69:38-47. doi: 10.1016/j.neurobiolaging.2018.04.022.

13. Bao J, Qin M, Mahaman YAR，Zhang B, Huang F, Zeng K, Xia Y, Ke D, Wang Q, Liu R, Wang JZ, Ye K, Wang XC*. BACE1 SUMOylation increases its stability and escalates the protease activity in Alzheimer’s disease. Proc Natl Acad Sci U S A. 2018 Apr 10;115(15):3954-3959. doi: 10.1073/pnas.1800498115.

14. Zhang Q, Xia Y, Wang Y, Shentu Y, Zeng K, Mahaman YAR, Huang F, Wu M, Ke D, Wang Q, Zhang B, Liu R, Wang JZ, Ye K, Wang XC*. CK2 Phosphorylating I2PP2A/SET Mediates Tau Pathology and Cognitive Impairment. Front Mol Neurosci. 2018 Apr 30;11:146. doi: 10.3389/fnmol.2018.00146. eCollection 2018.

15. Mahaman YAR, Huang F, Wu M, Wang Y, Wei Z, Bao J, Salissou MTM, Ke D, Wang Q, Liu R, Wang JZ, Zhang B, Chen D, Wang XC*. Moringa Oleifera Alleviates Homocysteine-Induced Alzheimer's Disease-Like Pathology and Cognitive Impairments. J Alzheimers Dis. 2018;63(3):1141-1159. doi: 10.3233/JAD-180091.

16. Zeng K, Li M, Hu J, Mahaman YAR, Bao J, Huang F, Xia Y, Liu X, Wang Q, Wang JZ, Yang Y, Liu R, Wang XC*. Ginkgo biloba extract EGb761 attenuates Hyperhomocysteinemia-induced AD like tau hyperphosphorylation and cognitive impairment in rats. Curr Alzheimer Res. 2018;15(1):89-99.

17. Liu X, Zeng K, Li M, Wang Q, Liu R, Zhang B, Wang JZ, Shu X, Wang XC*. Expression of P301L-hTau in mouse MEC induces hippocampus-dependent memory deficit. Sci Rep. 2017 Jun 20;7(1):3914. doi: 10.1038/s41598-017-04305-4.

18. Fang MS, Li X, Qian H, Zeng K, Ye M, Zhou YJ, Li H, Wang XC*, Li Y. ω-3PUFAs prevent MK-801-induced cognitive impairment in schizophrenic rats via the CREB/BDNF/TrkB pathway. J Huazhong Univ Sci Technolog Med Sci. 2017 Aug;37(4):491-495

19. Wang XC, Blanchard J, Tung YC, Grundke-Iqbal I, Iqbal K*. Inhibition of Protein Phosphatase-2A (PP2A) by I1PP2A Leads to Hyperphosphorylation of Tau, Neurodegeneration and Cognitive Impairment in Rats. J Alzheimers Dis. 2015 Jan 1;45(2):423-435. doi: 10.3233/JAD-142403.

20. Wang XC, Blanchard J, Grundke-Iqbal I, Wegiel J, Deng HX, Siddique T, Iqbal K. Alzheimer disease and amyotrophic lateral sclerosis: an etiopathogenic connection. Acta Neuropathol. 2014 Feb;127(2):243-256.

21. Luo HB, Xia YY, Shu XJ, Liu ZC, Feng Y, Liu XH, Yu G, Yin G, Xiong YS, Zeng K, Jiang J, Ye K, Wang XC*, Wang JZ*. SUMOylation at K340 inhibits tau degradation through deregulating its phosphorylation and ubiquitination. Proc Natl Acad Sci U S A. 2014 Nov 18;111(46):16586-16591.

22. Xia Y, Liu R, Chen R, Tian Q, Zeng K, Hu J, Liu X, Wang Q, Wang P, Wang XC*, Wang JZ*. Novel Multipotent AChEI-CCB Attenuates Hyperhomocysteinemia-Induced Memory Deficits and Neuropathologies in Rats. J Alzheimers Dis. 2014; 42(3):1029-1039.

23. Liu XH, Wang ZH, Xia YY, Yu G, Zeng K, Luo HB, Hu JC, Gong CX, Wang JZ, Zhou XW, Wang XC*. Losartan-induced hypotension leads to tau hyperphosphorylation and memory deficit. J Alzheimers Dis. 2014;40(2):419-27

24. Yu G, Yan TH, Feng Y, Liu XH, Xia YY, Luo HB, Wang JZ, Wang XC*. Ser9 phosphorylation causes cytoplasmic detention of I2PP2A/SET in Alzheimer disease. Neurobiology of Aging. 2013 Jul;34(7):1748-1758

25. Feng Y, Xia Y, Yu G, Shu X, Ge H, Zeng K, Wang J, Wang XC*. Cleavage of GSK-3β by calpain counteracts the inhibitory effect of Ser9 phosphorylation on GSK-3β activity induced by H2O2. J Neurochem. 2013 Jul; 126(2):234-42. doi: 10.1111/jnc.12285.

26. Feng Y, Wang XC*. Antioxidant therapies for Alzheimer's disease. Oxid Med Cell Longev. 2012;2012:472932. doi: 10.1155/2012/472932.

27. Yu G, Li Y, Tian Q, Liu R, Wang Q, Wang JZ, Wang XC*. Berberine Attenuates Calyculin A-Induced Cytotoxicity and Tau Hyperphosphorylation in HEK293 Cells. J Alzheimers Dis. 2011; 24(3):525-535

28. Wang XC, Blanchard J, Kohlbrenner E, Clement N, Linden RM, Radu A, Grundke-Iqbal I, Iqbal K. The carboxy-terminal fragment of inhibitor-2 of protein phosphatase-2A induces Alzheimer disease pathology and cognitive impairment. FASEB J. 2010; 24(11):4420-4432.

29. Wang XC*, Zhang YC, Chatterjie N, Grundke-Iqbal,I,.Iqbal K, Wang JZ, Effect of Melatonin and Melatonylvalpromide on beta-amyloid and Neurofilaments in N2a Cells. Neurochem Res. 2008; 33(6):1138-1144.

30. Wang XC, Du XX, Tian Q, Wang JZ. Correlation between Choline Signal Intensity and Acetylcholine Level in Different Brain Regions of Rat. Neurochem Res. 2008; 33(5):814-819.

31. Wang Q, Tian Q, Liu R, Liu ZZ, Hu MQ, Ke D, Zhang SH, Wang XC*. Pre-treatment of Melatonin against Oleic Acid-Induced Acute Lung Injury in Rats. Chinese Journal of Pathophysiology, 2007, 23(4): 767-771

32. Wang XC, Zhang J, Yu X, Han L, Zhou ZT, Zhang Y, Wang JZ. Prevention of isoproterenol-induced tau hyperphosphorylation by melatonin in the rat. Acta Physiologica Sinica. 2005; 57(1): 7-12

33. Wang XC, Hu ZH, Tang XW, Wu YG, Wang JZ. Correlation of Alzheimer-like tau abnormal hyperphosphorylation and fMRI BOLD signal intensity. Current Alzheimer Research. 2004; 1(2): 143-145
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Xiaochuan Wang

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