Yugang WANG

Personal Information

Title: Professor

Department: Department of Biochemistry and Molecular Biology

Email: yugangw@hust.edu.cn

Clinical Focus:

Research Focus/Interests: 1. The identification of novel type of histone modifications, including the regulatory mechanisms and roles in biological processes 2. The cross-talk between metabolism and the network of protein modifications.

Biography

March 2019-Present	      Professor
Department of Biochemistry and Molecular Biology, Tongji Medical College, Huazhong University of Science & Technology, Wuhan, China
January 2018-March 2019	      Instructor
Department of Neuro-oncology, University of Texas, M.D. Anderson Cancer Center, Houston, TX
October 2012-Janunary 2018     Postdoctoral Fellow
Department of Neuro-oncology, University of Texas, M.D. Anderson Cancer Center, Houston, TX
September 2008-June 2012        Graduate Research Assistant
School of Life Sciences, Tsinghua University, Beijing, China

Honors & Awards:
2018	The Third Prize, Outstanding Performance and Excellence in Scientific Presentation. Society of Chinese Bioscientists in America, Texas Chapter. Houston, TX
2017	Odyssey Outstanding Research Publication Award. M.D. Anderson Cancer Center. Houston, TX.
2011	The First Prize, Scholarship award for Ph.D. candidates. Tsinghua University. Beijing, China
2010	The Second Prize, Scholarship award for Ph.D. candidates. Tsinghua University. Beijing, China
2008	Outstanding Graduate Award-Hunan Province. Changsha, China
2007	The Third Prize, The National Challenge-cup Extracurricular and Academic Contest. Tianjin, China
2006	The Top Prize, Hunan Challenge-cup Extracurricular and Academic Contest. Xiangtan, China

Education

2008-2012	Ph.D., Biochemistry and Pharmacology
Tsinghua University, Beijing, China
Mentor: Lijun Du M.D., Ph.D.
2004-2008	B.S., Biology
Hunan Normal University, Changsha, China

Boards, Advisory Committees, Professional Organizations

Journal Reviewer, Cancer Research, since 2013
Journal Reviewer, Clinical and Experimental Metastasis, since 2014
Journal Reviewer, Chinese Journal of Natural Medicines, since 2014
Journal Reviewer, Acta Pharmacologica Sinic, since 2014
Journal Reviewer, Cancer Letters, since 2016
Journal Reviewer, Anti-Cancer Drugs, since 2016

Publications

1.	Lu S, Wang Y# (Corresponding author). Non-metabolic functions of metabolic enzymes in cancer development. Cancer communications. 2018; 28:65.
2.	Wang Y, Xia Y, Lu Z. Metabolic features of cancer cells. Cancer communications. 2018; 28:63.
3.	Wang Y*, Guo YR*, Xing D, Tao YJ, Lu Z. Supramolecular assembly of KAT2A with succinyl-CoA for histone succinylation. Cell Discovery. 2018; 4:47. * Equal Contribution. 
4.	Li X, Egervari G, Wang Y, Berger SL, Lu Z. Regulation of chromatin and gene expression by metabolic enzymes and metabolites. Nature Reviews Molecular Cell Biology. 2018; 19:563-578.
5.	Lee JH, Liu R, Li J, Wang Y, Tan L, Li XJ, Qian X, Zhang C, Xia Y, Xu D, Guo W, Ding Z, Du L, Zheng Y, Chen Q, Lorenzi PL, Mills GD, Jiang T, Lu Z. EGFR-phosphorylated platelet isoform of phosphofructokinase 1 promotes PI3K activation. Molecular Cell. 2018; 70(2):197-210.e7
6.	Wang Y*, Guo YR*, Liu K, Yin Z, Liu R, Xia Y, Tan L, Yang P, Lee JH, Li XJ, Hawke D, Zheng Y, Qian X, Lyu J, He J, Xing D, Tao YJ, Lu Z. KAT2A coupled with the α-KGDH complex acts as a histone H3 succinyltransferase. Nature. 2017; 552(7684):273-277. * Equal Contribution. (Highlighted in Cancer Discovery and M.D. Anderson News Release)
7.	Lee JH, Liu R, Li J, Zhang C, Wang Y, Cai Q, Qian Xm Xia Y, Zheng Y, Piao Y, Chen Q, de Groot JF, Jiang T, Lu Z. Stabilization of phosphofructokinase 1 platelet isoform by AKT promotes tumorigenesis. Nature Communications. 2017; 8(1):949.
8.	Xia Y, Yang W, Fa M, Li X, Wang Y, Jiang Y, Zheng Y, Lee JH, Li J, Lu Z. RNF8 mediates histone H3 ubiquitylation and promotes glycolysis and tumorigenesis. The Journal of Experimental Medicine. 2017; 214(6):1843-1855.
9.	Qian X, Li X, Cai Q, Zhang C, Yu Q, Jiang Y, Lee JH, Hawke D, Wang Y, Xia Y, Zheng Y, Jiang BH Liu DX, Jiang T, Lu Z. Phosphoglycerate kinase 1 phosphorylates Beclin 1 to induce autophagy. Molecular Cell. 2017; 65(5):917-931.e6. 
10.	Ji H, Lee JH, Wang Y, Pang Y, Zhang T, Xia Y, Zhong L, Lyu J, Lu Z. EGFR phosphorylates FAM129B to promote Ras activation. Proceedings of the National Academy of Sciences of the United States of America. 2016; 113(3):644-9.
11.	Zheng Y, Li X, Qian X, Wang Y, Lee JH, Xia Y, Hawke DH, Zhang G, Lyu J, Lu Z. Secreted and O-GlcNAcylated MIF binds to the human EGF receptor and inhibits its activation. Nature cell biology. 2015; 17(10):1348-55.
12.	Jiang Y, Qian X, Shen J, Wang Y, Li X, Liu R, Xia Y, Chen Q, Peng G, Lin SY, Lu Z. Local generation of fumarate promotes DNA repair through inhibition of histone H3 demethylation. Nature cell biology. 2015; 17(9):1158-68.
13.	Jiang Y, Wang Y, Wang T, Hawke DH, Zheng Y, Li X, Zhou Q, Majumder S, Bi E, Liu DX, Huang S, Lu Z. PKM2 phosphorylates MLC2 and regulates cytokinesis of tumour cells. Nature communications. 2014; 5:5566. NIHMSID: NIHMS635667.
14.	Jiang JF*, Wang YG*, Hu J*, Lei F, Kheir MM, Wang XP, Chai YS, Yuan ZY, Lu X, Xing DM, Du F, Du LJ. Novel effect of berberine on thermoregulation in mice model induced by hot and cold environmental stimulation. PLOS ONE. 2013; 8(1): e54234. * Equal Contribution.
15.	Wang Y*, Kheir MM*, Chai Y, Hu J, Xing D, Lei F, Du L. Comprehensive study in the inhibitory effect of berberine on gene transcription, including TATA box. PLOS ONE. 2011; 6(8): e23495. * Equal Contribution.
16.	Wang Y, Li L, Li H, Zhu Z, Hua L, Lei F, Kheir MM, Du L. Transdermal permeation of geniposide in the herbal complex liniment in vivo and in vitro. International journal of pharmaceutics. 2010; 392(1-2):72-7. 
17.	Kheir MM*, Wang Y*, Hua L, Hu J, Li L, Lei F, Du L. Acute toxicity of berberine and its correlation with the blood concentration in mice. Food and chemical toxicology. 2010; 48(4):1105-10. * Equal Contribution.

Oral Presentation:
1.	KAT2A coupled with the α-KGDH complex acts as a histone H3 succinyltransferase. Society of Chinese Bioscientists in America (SCBA), 2018, 32nd Annual Symposium. Houston, Texas, USA. May 12, 2018.
2.	Mechanism Underlying Histone H3 Succinylation. Cancer Metabolism Working Group Seminars. Houston, Texas, USA. February 22, 2018
3.	The function and underlying mechanism of histone succinylation in cancer development. “Metabolism in Cancer” Symposium at MD Anderson Cancer Center. September 20, 2018.

Poster Presentation:
1.	KAT2A coupled with the α-KGDH complex acts as a histone H3 succinyltransferase. Keystone Symposia on Molecular and Cellular Biology, Cancer Epigenetics: New Mechanism, New Therapies (B4). Breckenridge, Colorado, USA. February 10-14, 2018.

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Yugang WANG

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