Jianzhi WANG

Personal Information

Title: Professor

Department: Department of Pathophysiology

Email: wangjz@mail.hust.edu.cn/wangjz@mails.tjmu.edu.cn

Clinical Focus:

Research Focus/Interests: 1. Alzheimer disease including its pathogenesis, early diagnosis and prevention; 2. emotion and learning memory, neurodevelopment and neural circuitry.

Biography

1996-present    full-time professor and mentor of PhD students
Department of Pathophysiology, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
1993-1996      Postdoctoral Research in Alzheimer disease
NYS Institute for Basic Research, SI, NY, USA
1992-1993      Postdoctoral Research in Biochemistry
Siena University, Siena, Italy
1978-1992      teaching assistant, lecturer, associate professor
Department of Biochemistry, Tongji Medical University, Wuhan, China

Honors & Awards:
2010   Second-grand Award of Natural Science Research in Alzheimer Disease, the State Council of China 
2009  First-grade Award of Natural Science Research in Alzheimer disease, Ministry of Education of China
2008  First-grade Award of Natural Science Research in Alzheimer disease, Government of Hubei Province
2008  Second-grand Award Natural Science Research in Alzheimer disease, Chinese Medical Association
2004  First-grade Award of Natural Science Research in Alzheimer disease, Ministry of Education of China
2002  First-grade Award of Chinese Medicine, Chinese Medical Association
2000  Second-grade Award of in Alzheimer Disease Research, Government of Hubei Province

Education

1993-1996      Postdoctoral Research in Alzheimer disease
NYS Institute for Basic Research, SI, NY, USA 
1992-1993      Postdoctoral Research in Biochemistry
Siena University, Siena, Italy
1989-1990      Visiting scientist
Biochemistry Institute of Shanghai, Chinese Academy of Science
1985-1988      Post Graduate Training in Biochemistry
Tongji Medical University, Wuhan, China, M.S.
1975-1978      Undergraduate Study in General Medicine
Wuhan Medical College (i.e., Tongji Medical College), Wuhan, China, M.D. (equivalence)

Boards, Advisory Committees, Professional Organizations

Vice Chairperson, Pathophysiology Association of China (2004-2014)
Vice Chairperson, International Association of Pathophysiology (2014-present)
Executive Member, Pathophysiology Association of China (2014-present)
Member, Neuroscience Association of China (2015-present)
Chairperson, Pathophysiology Association of Hubei Province (2010-present)
Ad Hoc reviewer for Natural Science Foundation of China (NSFC), Ministry of Science and Technology of China (MOST), and Ministry of Education of China (1996-present)
Associate Editor, Neuroscience Bulletin & Frontier of Medicine & Journal of Alzheimer Disease & Journal of Neurochemistry (handling editor), etc.
Chief Editor, Pathophysiology, both in Chinese (6th, 7th and 8th editions), and in English (1st and 2nd editions)

Publications

1.	Zheng J, Li HL, Tian N, Liu F, Wang L, Yin Y, Yue L, Ma L, Wan Y, Wang JZ. Interneuron Accumulation of Phosphorylated tau Impairs Adult Hippocampal Neurogenesis by Suppressing GABAergic Transmission. Cell Stem Cell. 2020 Mar 5;26(3):331-345.e6. doi: 10.1016/j.stem.2019.12.015. 
2.	Wang ZH, Liu P, Liu X, Manfredsson FP, Sandoval IM, Yu SP, Wang JZ, Ye K. Delta-Secretase Phosphorylation by SRPK2 Enhances Its Enzymatic Activity, Provoking Pathogenesis in Alzheimer's Disease. Mol Cell. 2017 Sep 7;67(5):812-825.e5. doi: 10.1016/j.molcel.2017.07.018. Epub 2017 Aug 17. 
3.	Pi G, Gao D, Wu D, Wang Y, Lei H, Zeng W, Gao Y, Yu H, Xiong R, Jiang T, Li S, Wang X, Guo J, Zhang S, Yin T, He T, Ke D, Li R, Li H, Liu G, Yang X, Luo MH, Zhang X, Yang Y, Wang JZ. Posterior basolateral amygdala to ventral hippocampal CA1 drives approach behaviour to exert an anxiolytic effect. Nat Commun. 2020 Jan 10;11(1):183. doi: 10.1038/s41467-019-13919-3.
4.	Zhang Z, Li XG, Wang ZH, Song M, Yu SP, Kang SS, Liu X, Zhang Z, Xie M, Liu GP, Wang JZ, Ye K. δ-Secretase-cleaved Tau stimulates Aβ production via upregulating STAT1-BACE1 signaling in Alzheimer's disease. Mol Psychiatry. 2021 Feb;26(2):586-603. doi: 10.1038/s41380-018-0286-z. Epub 2018 Oct 31. 
5.	Wang ZH, Liu P, Liu X, Yu SP, Wang JZ, Ye K. Delta-secretase (AEP) mediates tau-splicing imbalance and accelerates cognitive decline in tauopathies. J Exp Med. 2018 Dec 3;215(12):3038-3056. doi: 10.1084/jem.20180539. Epub 2018 Oct 29. 
6.	Wang ZH, Gong K, Liu X, Zhang Z, Sun X, Wei ZZ, Yu SP, Manfredsson FP, Sandoval IM, Johnson PF, Jia J, Wang JZ, Ye K. C/EBPβ regulates delta-secretase expression and mediates pathogenesis in mouse models of Alzheimer's disease. Nat Commun. 2018 May 3;9(1):1784. doi: 10.1038/s41467-018-04120-z. 
7.	Zhang Z, Kang SS, Liu X, Ahn EH, Zhang Z, He L, Iuvone PM, Duong DM, Seyfried NT, Benskey MJ, Manfredsson FP, Jin L, Sun YE, Wang JZ, Ye K. Asparagine endopeptidase cleaves α-synuclein and mediates pathologic activities in Parkinson's disease. Nat Struct Mol Biol. 2017 Aug;24(8):632-642. doi: 10.1038/nsmb.3433. Epub 2017 Jul 3. 
8.	Zhang Z, Obianyo O, Dall E, Du Y, Fu H, Liu X, Kang SS, Song M, Yu SP, Cabrele C, Schubert M, Li X, Wang JZ, Brandstetter H, Ye K. Inhibition of delta-secretase improves cognitive functions in mouse models of Alzheimer's disease. Nat Commun. 2017 Mar 27;8:14740. doi: 10.1038/ncomms14740. 
9.	Yang Y, Wang ZH, Jin S, Gao D, Liu N, Chen SP, Zhang S, Liu Q, Liu E, Wang X, Liang X, Wei P, Li X, Li Y, Yue C, Li HL, Wang YL, Wang Q, Ke D, Xie Q, Xu F, Wang L, Wang JZ. Opposite monosynaptic scaling of BLP-vCA1 inputs governs hopefulness- and helplessness-modulated spatial learning and memory. Nat Commun. 2016 Jul 14;7:11935. doi: 10.1038/ncomms11935. 
10.	Liu D, Wei N, Man HY, Lu Y, Zhu LQ, Wang JZ. The MT2 receptor stimulates axonogenesis and enhances synaptic transmission by activating Akt signaling. Cell Death Differ. 2015 Apr;22(4):583-96. doi: 10.1038/cdd.2014.195. Epub 2014 Dec 12. 
11.	Yang Y, Shu X, Liu D, Shang Y, Wu Y, Pei L, Xu X, Tian Q, Zhang J, Qian K, Wang YX, Petralia RS, Tu W, Zhu LQ, Wang JZ, Lu Y. EPAC null mutation impairs learning and social interactions via aberrant regulation of miR-124 and Zif268 translation. Neuron. 2012 Feb 23;73(4):774-88. doi: 10.1016/j.neuron.2012.02.003. 
12.	Yu H, Liu Y, He B, He T, Chen C, He J, Yang X, Wang JZ. Platelet biomarkers for a descending cognitive function: A proteomic approach. Aging Cell. 2021 May;20(5):e13358. doi: 10.1111/acel.13358. Epub 2021 May 4. 
13.	Wang W, Zhou Q, Jiang T, Li S, Ye J, Zheng J, Wang X, Liu Y, Deng M, Ke D, Wang Q, Wang Y, Wang JZ. A novel small-molecule PROTAC selectively promotes tau clearance to improve cognitive functions in Alzheimer-like models. Theranostics. 2021 Mar 11;11(11):5279-5295. doi: 10.7150/thno.55680. 
14.	Liu F, Tian N, Zhang HQ, Li SH, Zhou QZ, Yang Y, Zheng J, Wang JZ. GSK-3β activation accelerates early-stage consumption of Hippocampal Neurogenesis in senescent mice. Theranostics. 2020 Aug 1;10(21):9674-9685. doi: 10.7150/thno.43829.
15.	Ye J, Yin Y, Yin Y, Zhang H, Wan H, Wang L, Zuo Y, Gao D, Li M, Li J, Liu Y, Ke D, Wang JZ. Tau-induced upregulation of C/EBPβ-TRPC1-SOCE signaling aggravates tauopathies: A vicious cycle in Alzheimer neurodegeneration. Aging Cell. 2020 Sep;19(9):e13209. doi: 10.1111/acel.13209. Epub 2020 Aug 20. 
16.	Liu E, Zhou Q, Xie AJ, Li X, Li M, Ye J, Li S, Ke D, Wang Q, Xu ZP, Li L, Yang Y, Liu GP, Wang XC, Li HL, Wang JZ. Tau acetylates and stabilizes β-catenin thereby promoting cell survival. EMBO Rep. 2020 Mar 4;21(3):e48328. doi: 10.15252/embr.201948328. Epub 2020 Jan 13. 
17.	Ye J, Yin Y, Liu H, Fang L, Tao X, Wei L, Zuo Y, Yin Y, Ke D, Wang JZ. Tau inhibits PKA by nuclear proteasome-dependent PKAR2α elevation with suppressed CREB/GluA1 phosphorylation. Aging Cell. 2020 Jan;19(1):e13055. doi: 10.1111/acel.13055. Epub 2019 Oct 31. 
18.	Wang ZH, Xiang J, Liu X, Yu SP, Manfredsson FP, Sandoval IM, Wu S, Wang JZ, Ye K. Deficiency in BDNF/TrkB Neurotrophic Activity Stimulates δ-Secretase by Upregulating C/EBPβ in Alzheimer's Disease. Cell Rep. 2019 Jul 16;28(3):655-669.e5. doi: 10.1016/j.celrep.2019.06.054.
19.	Feng Q, Luo Y, Zhang XN, Yang XF, Hong XY, Sun DS, Li XC, Hu Y, Li XG, Zhang JF, Li X, Yang Y, Wang Q, Liu GP, Wang JZ. MAPT/Tau accumulation represses autophagy flux by disrupting IST1-regulated ESCRT-III complex formation: a vicious cycle in Alzheimer neurodegeneration. Autophagy. 2020 Apr;16(4):641-658. doi: 10.1080/15548627.2019.1633862. Epub 2019 Jun 28. 
20.	Li XG, Hong XY, Wang YL, Zhang SJ, Zhang JF, Li XC, Liu YC, Sun DS, Feng Q, Ye JW, Gao Y, Ke D, Wang Q, Li HL, Ye K, Liu GP, Wang JZ. Tau accumulation triggers STAT1-dependent memory deficits by suppressing NMDA receptor expression. EMBO Rep. 2019 Jun;20(6):e47202. doi: 10.15252/embr.201847202. Epub 2019 May 13.
21.	Xie AJ, Hou TY, Xiong W, Huang HZ, Zheng J, Li K, Man HY, Hu YZ, Han ZT, Zhang HH, Wei N, Wang JZ, Liu D, Lu Y, Zhu LQ. Tau overexpression impairs neuronal endocytosis by decreasing the GTPase dynamin 1 through the miR-132/MeCP2 pathway. Aging Cell. 2019 Jun;18(3):e12929. doi: 10.1111/acel.12929. Epub 2019 Feb 27. 
22.	Chai GS, Feng Q, Wang ZH, Hu Y, Sun DS, Li XG, Ke D, Li HL, Liu GP, Wang JZ. Downregulating ANP32A rescues synapse and memory loss via chromatin remodeling in Alzheimer model. Mol Neurodegener. 2017 May 4;12(1):34. doi: 10.1186/s13024-017-0178-8. 
23.	Li X, Wang Z, Tan L, Wang Y, Lu C, Chen R, Zhang S, Gao Y, Liu Y, Yin Y, Liu X, Liu E, Yang Y, Hu Y, Xu Z, Xu F, Wang J, Liu GP, Wang JZ. Correcting miR92a-vGAT-Mediated GABAergic Dysfunctions Rescues Human Tau-Induced Anxiety in Mice. Mol Ther. 2017 Jan 4;25(1):140-152. doi: 10.1016/j.ymthe.2016.10.010. Epub 2017 Jan 4. 
24.	Yin Y, Gao D, Wang Y, Wang ZH, Wang X, Ye J, Wu D, Fang L, Pi G, Yang Y, Wang XC, Lu C, Ye K, Wang JZ. Tau accumulation induces synaptic impairment and memory deficit by calcineurin-mediated inactivation of nuclear CaMKIV/CREB signaling. Proc Natl Acad Sci U S A. 2016 Jun 28;113(26):E3773-81. doi: 10.1073/pnas.1604519113. Epub 2016 Jun 13. 
25.	Luo HB, Xia YY, Shu XJ, Liu ZC, Feng Y, Liu XH, Yu G, Yin G, Xiong YS, Zeng K, Jiang J, Ye K, Wang XC, Wang JZ. SUMOylation at K340 inhibits tau degradation through deregulating its phosphorylation and ubiquitination. Proc Natl Acad Sci U S A. 2014 Nov 18;111(46):16586-91. doi: 10.1073/pnas.1417548111. Epub 2014 Nov 5. 
26.	Liu GP, Wei W, Zhou X, Shi HR, Liu XH, Chai GS, Yao XQ, Zhang JY, Peng CX, Hu J, Li XC, Wang Q, Wang JZ. Silencing PP2A inhibitor by lenti-shRNA interference ameliorates neuropathologies and memory deficits in tg2576 mice. Mol Ther. 2013 Dec;21(12):2247-57. doi: 10.1038/mt.2013.189. Epub 2013 Aug 7. 
27.	Li HL, Wang HH, Liu SJ, Deng YQ, Zhang YJ, Tian Q, Wang XC, Chen XQ, Yang Y, Zhang JY, Wang Q, Xu H, Liao FF, Wang JZ. Phosphorylation of tau antagonizes apoptosis by stabilizing beta-catenin, a mechanism involved in Alzheimer's neurodegeneration. Proc Natl Acad Sci U S A. 2007 Feb 27;104(9):3591-6. doi: 10.1073/pnas.0609303104. Epub 2007 Feb 21.

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Jianzhi WANG

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