Pengfei WU

Personal Information

Title: Associate Professor

Department: Department of Pharmacology

Email: wupengfeipharm@foxmail.com

Clinical Focus:

Research Focus/Interests: Neuropsychopharmacology, Redox biology, Translational medicine

Biography

2017-2021   Associated Professor, Department of Pharmacology, School of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology
2012-2016   Lecturer, Department of Pharmacology, School of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology

Education

2012   PhD in Pharmacology, Huazhong University of Science and Technology, Wuhan, China 
2007   BS in Biological Pharmacy, Huazhong University of Science and Technology, Wuhan, China

Boards, Advisory Committees, Professional Organizations

Member, Division of Neuropsychopharmacology, Chinese Pharmacological Society

Publications

1.	Wu PF, Guan XL, Wang F, Chen JG.N-acetylcysteine facilitates extinction of cued fear memory in rats via reestablishing basolateral amygdala glutathione homeostasis.Acta Pharmacol Sin2021 Apr 29. doi: 10.1038/s41401-021-00661-0.
2.	Chen FF, Wang CM, Chen HS, Wang J, Han QQ, Cao Y, Shen TT, Yang YJ, Hu ZL, Wang F, Chen JG, Wu PF.SKF83959, an agonist of phosphatidylinositol-linked dopamine receptors, prevents renewal of extinguished conditioned fear and facilitates extinction.Brain Res 2020;1749:147136.
3.	Xu JF, Lu JJ, Cao Y, Wang W, Li HH, Chen JG, Wang F, Wu PF.Sulforaphane alleviates ethanol-mediated central inhibition and reverses chronic stress-induced aggravation of acute alcoholism via targeting Nrf2-regulated catalase expression.Neuropharmacology2020;176:108235.
4.	Luo H, Wu PF(co-first author), Cao Y, Jin M, Shen TT, Wang J, Huang JG, Han QQ, He JG, Deng SL, Ni L, Hu ZL, Long LH, Wang F, Chen JG.Angiotensin-Converting Enzyme Inhibitor Rapidly Ameliorates Depressive-Type Behaviors via Bradykinin-Dependent Activation of Mammalian Target of Rapamycin Complex 1.Biol Psychiatry2020;88(5):415-425.
5.	Shen ZC,Wu PF (co-first author),Wang F, Deng Q, Nie TL, Zhang SQ, Zheng HL, Liu WH, Lu JJ, Gao SQ, Yao XP, Long LH, Hu ZL, Chen JG. Gephyrin Palmitoylation in Basolateral Amygdala Mediates the Anxiolytic Action of Benzodiazepine.Biological Psychiatry2019;85(3):202-213.
6.	Xia ZX, Shen ZC, Zhang SQ, Wang J, Nie TL, Deng Q, Chen JG, Wang F,Wu PF.De-palmitoylation by N-(tert-Butyl) hydroxylamine inhibits AMPAR-mediated synaptic transmission via affecting receptor distribution in postsynaptic densities.CNS NeurosciTher2019;25(2):187-199.
7.	Luo H,Wu PF (co-first author), Han QQ, Cao Y, Deng SL, Wang J, Deng Q, Wang F, Chen JG. Reactive Sulfur Species Emerge as Gliotransmitters to Support Memory via Sulfuration-Dependent Gating of NR2A-Containing N-Methyl-d-Aspartate Subtype Glutamate Receptor Function.Antioxid Redox Signal2019; 30(16):1880-1899.
8.	Guan XL, Wu PF (co-first author), Wang S, Zhang JJ, Shen ZC, Luo H, Chen H, Long LH, Chen JG, Wang F. Dimethyl sulfide protects against oxidative stress and extends lifespan via a methionine sulfoxide reductase A-dependent catalytic mechanism. Aging Cell 2017; 16(2):226-236. 
9.	Li YL, Wu PF (co-first author), Chen JG, Wang S, Han QQ, Li D, Wang W, Guan XL, Li D, Long LH, Huang JG, Wang F. Activity-Dependent Sulfhydration Signal Controls N-Methyl-D-Aspartate Subtype Glutamate Receptor-Dependent Synaptic Plasticity via Increasing d-Serine Availability. Antioxid Redox Signal 2017; 27(7):398-414. 
10.	Fan H, Wu PF (co-first author), Zhang L, Hu ZL, Wang W, Guan XL, Luo H, Ni M, Yang JW, Li MX, Chen JG, Wang F. Methionine sulfoxide reductase A negatively controls microglia-mediated neuroinflammation via inhibiting ROS/MAPKs/NF-κB signaling pathways through a catalytic antioxidant function. Antioxid Redox Signal 2015, 22(10):832-47. 
11.	Lu HF, Wu PF (co-first author), Yang YJ, Xiao W, Fan J, Liu J, Li YL, Luo Y, Hu ZL, Jin Y, Wang F, Chen JG. Interactions between N-ethylmaleimide-sensitive factor and GluR2 in the nucleus accumbens contribute to the expression of locomotor sensitization to cocaine. J Neurosci. 2014, 34(10):3493-508. 
12.	Han J, Zhang H, Wang S, Zhou J, Luo Y, Long LH, Hu ZL, Wang F, Chen JG, Wu PF (Corresponding author). Potentiation of Surface Stability of AMPA Receptors by Sulfhydryl Compounds: A Redox-Independent Effect by Disrupting Palmitoylation. Neurochem Res. 2016, 41(11):2890-2903. 
13.	Li YL, Zhou J, Zhang H, Luo Y, Long LH, Hu ZL, Chen JG, Wang F, Wu PF (Corresponding author). Hydrogen Sulfide Promotes Surface Insertion of Hippocampal AMPA Receptor GluR1 Subunit via Phosphorylating at Serine-831/Serine-845 Sites Through a Sulfhydration-Dependent Mechanism. CNS Neurosci Ther. 2016, 22(9):789-98. 
14.	Wang X, Cao H, Guan XL, Long LH, Hu ZL, Ni L, Wang F, Chen JG, Wu PF (Corresponding author). Sulfite triggers sustained calcium overload in cultured cortical neurons via a redox-dependent mechanism. Toxicol Lett. 2016, 258:237-48. 
15.	Ma J, Long LH, Hu ZL, Zhang H, Han J, Ni L, Wang F, Chen JG, Wu PF (Corresponding author). Activation of D1-like receptor-dependent phosphatidylinositol signal pathway by SKF83959 inhibits voltage-gated sodium channels in cultured striatal neurons. Brain Res. 2015, 1615:71-9.

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Pengfei WU

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