Weimin WANG

Personal Information

Title: Professor

Department: Department of Immunology

Email: weiminw@hust.edu.cn

Clinical Focus:

Research Focus/Interests:

Biography

2019-present        Professor of Immunology, Tongji Medical College, Huazhong University of Science and Technology (HUST), Wuhan, China
2013-2019           Postdoctoral research fellow, Department of Surgery, University of Michigan Medical School, Ann Arbor, Michigan, USA
2011-2013           Postdoctoral research fellow, Department of Obstetrics and Gynecology, University of Michigan Medical School, Ann Arbor, Michigan, USA

Courses Taught:
1001111 Medical Immunology (undergraduate)
510.523 Experimental Immunology (graduate)
510.814 Proceedings of Immunology (graduate)
510.808 Medical Research(graduate)

Education

2006-2011     Ph.D., Biochemistry and Molecular Biology, Institute Of Basic Medical Science, Peking Union Medical College/Tsinghua University, Beijing, China
2002-2006     B.S., Biotechnology, National Base of Life Science and Biotechnology, College of Life Sciences, Lanzhou University, Lanzhou, China

Boards, Advisory Committees, Professional Organizations

Publications

1.	Wang W*, Zou W*. Amino acid and their transporters in T cell immunity and cancer therapy. Molecular Cell. 2020 Nov; 80(3):384-395 (co-corresponding)
2.	Wang W, Green M, Choi JE, Gijón M, Kennedy PD, Johnson JK, Liao P, Lang X, Kryczek I, Sell A, Xia H, Zhou J, Li G, Li J, Li W, Wei S, Vatan L, Zhang H, Szeliga W, Gu W, Liu R, Lawrence TS, Lamb C, Tanno Y, Cieslik M, Stone E, Georgiou G, Chan TA, Chinnaiyan A, Zou W. CD8+ T cells regulate tumour ferroptosis during cancer immunotherapy. Nature. 2019 May;569(7755):270-274.
3.	Wang W, Kryczek I, Dostál L, Lin H, Tan L, Zhao L, Lu F, Wei S, Maj T, Peng D, He G, Vatan L, Szeliga W, Kuick R, Kotarski J, Tarkowski R, Dou Y, Rattan R, Munkarah A, Liu JR, Zou W. Effector T cells abrogate stroma-mediated chemoresistance in ovarian cancer. Cell. 2016 May 19; 165(5): 1092-105.
4.	Wang W, Zou W, Liu R. Tumor-infiltrating T cells in epithelial ovarian cancer: predictors of prognosis and biological basis of immunotherapy. Gynecol Oncol. 2018 Oct;151(1):1-3. 
5.	Wang W, Liu JR, Zou W. Immunotherapy in Ovarian Cancer. Surg Oncol Clin N Am. 2019 Jul; 28(3):447-464.
6.	Wang W, Green M, Liu R, Lawrence T, Zou W. CD8+ T cells in Immunotherapy, Radiotherapy and Chemotherapy. Oncoimmunology, 2018. doi.org/10.1007/978-3-319-62431-0_3. 
7.	Wang W, Zhou J, Zhang Y, Liu S, Liu Y, Zheng D. HTLV-1 Tax-deregulated both autophagy pathway and c-FLIP expression contribute to the resistance against death receptor-mediated apoptosis. J Virol. 2014 Mar; 88(5):2786-98.
8.	Lang X, Green MD, Wang W, Yu J, Choi JE, Jiang L, Liao P, Zhou J, Zhang Q, Dow A, Saripalli AL, Kryczek I, Wei S, Szeliga W, Vatan L, Stone EM, Georgiou G, Cieslik M, Wahl DR, Morgan MA, Chinnaiyan AM, Lawrence TS, Zou W. Radiotherapy and Immunotherapy Promote Tumoral Lipid Oxidation and Ferroptosis via Synergistic Repression of SLC7A11. Cancer Discov. 2019 Dec; 9(12):1673-1685.
9.	Maj T, Wang W, Wang W, Wei S, Zhao L, Linda Vatan L, Szeliga W, Liu R, Kryczek I, Zou W. Oxidative stress controls regulatory T cell apoptosis and suppressor activity and PD-L1 blockade in the tumor microenvironment. Nat Immunol, 2017 Dec;18(12):1332-1341.
10.	Tan L, Wang W, He G, Kuick RD, Gossner G, Kueck AS, Wahl H, Opipari AW, Liu JR. Resveratrol inhibits ovarian tumor growth in an in vivo mouse model. Cancer. 2016 Mar 1; 122(5): 722-9.
11.	Peng D, Kryczek I, Nagarsheth N, Zhao L, Wei S, Wang W, Sun Y, Zhao E, Vatan L, Szeliga W, Kotarski J, Tarkowski R, Dou Y, Cho K, Hensley-Alford S, Munkarah A, Liu R, Zou W. Epigenetic silencing of TH1-type chemokines shapes tumour immunity and immunotherapy. Nature. 2015 Nov 12; 527(7577): 249-53
12.	Tang W, Wang W, Zhang Y, Liu S, Liu Y, Zheng D. TRAIL receptor mediates inflammatory cytokine release in an NF-kappaB-dependent manner. Cell Res. 2009 Jun; 19(6):758-67.
13.	Song C, Wang W, Li M, Liu Y, Zheng D. Tax1 enhances cancer cell proliferation via Ras-Raf-MEK-ERK signaling pathway. IUBMB Life. 2009 Jun; 61(6):685-92.
14.	Tang W, Wang W, Zhang Y, Liu S, Liu Y, Zheng D. Tumour necrosis factor-related apoptosis-inducing ligand (TRAIL)-induced chemokine release in both TRAIL- resistant and TRAIL-sensitive cells via nuclear factor kappa B. FEBS J. 2009 Jan; 276(2):581-93.
15.	Wang S, Wang W, Guo Y, Guo YY, Wei J, Zhang Y. Acute and chronic toxicity of chromium and cadmium on grass carp flies (Ctenopharyngodon ideUus). J Lanzhou Univ. 2007 Aug; 43(4):60-64.

Projects:
1.	The mechanism of SLC7A11 in tumor ferroptosis regulated by interferon-gamma. National Natural Science Foundation of China (81902930), 2020-2022
2.	The effects of fatty acids metabolism on cancer ferroptosis and immune response. The Fundamental Research Funds for the Central Universities (2021GCRC072), 2020-2026
3.	The regulation of ACSL4-mediated arachidonic acid metabolism on ferroptosis and anti-tumor immunity. National Natural Science Foundation of China (82073177), 2021-2024

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Weimin WANG

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