Hui WANG

Personal Information

Title: Associate Professor

Department: Department of Medical Genetics

Email: wanghuipitt@hust.edu.cn

Clinical Focus:

Research Focus/Interests: Sterile inflammation and innate immune, sepsis and epigenetics

Biography

2017-present   Associate Professor, Department of Medical genetics, Huazhong University of Science and Technology
2004-2016      Lecturer, Department of Medical genetics, Huazhong University of Science and Technology
2011-2012       Visiting Scholar, Department of Surgery, University of Pittsburgh Medical Centre
1999-2004       Teaching Assistant, Department of Medical genetics, Huazhong University of Science and Technology

Education

2007   PhD in Medical Immunology, Huazhong University of Science and technology, 
2004   MS in Medical genetics, Huazhong University of Science and technology
1999   BS in Clinical medicine, Tongji medical college

Boards, Advisory Committees, Professional Organizations

Publications

1.	Wen-Ming Pan# ; Hui Wang# ; Xiao-Fei Zhang; Peng Xu; Guo-Liang Wang; Yi-Jing Li; Kun-Peng Huang; Yun-Wei Zhang; Huan Zhao; Run-Lei Du; Hai Huang;Xiao-Dong Zhang* ; Jin-Xiang Zhang* ; miR-210 Participates in Hepatic Ischemia Reperfusion Injury by Forming a Negative Feedback Loop With SMAD4, Hepatology,2020, 72(6): 2134-2148.  
2.	Wenming Pan#, Lin Wang#, Xiao-Fei Zhang#, Hongji Zhang#, Jinxiang Zhang, Guoliang Wang, Peng Xu, Yunwei Zhang, Ping Hu, Xiao-Dong Zhang, Run-Lei Du*, 
3.	Hui Wang*.Hypoxia-induced microRNA-191 contributes to hepatic ischemia/reperfusion injury through the ZONAB/Cyclin D1 axis,Cell Death and Differentiation,2019 Jan;26(2):291-305.
4.	Rongfu Tu, Wenqian Kang, Xuefei Yang, Qi Zhang, Xiaoyu Xie, Wenbin Liu, Jinxiang Zhang,Xiao-Dong Zhang, Hui Wang* and Run-Lei Du*.USP49 participates in the DNA damage response by forming a positive feedback loop with p53. Cell Death & Disease, (2018) 9(5):553.
5.	Ning Wang#, Hui Wang#, Chengchun Tang, Shijun Lei, Wanqing Shen, Cong Wang, Guobin Wang, Zheng Wang*, Lin Wang*.Toxicity evaluation of boron nitride nanospheres and water-soluble boron nitride in Caenorhabditis elegans. International Journal of Nanomedicine, 2017,12:5941-5957.
6.	Hui Wang#, Guoliang Wang, Liyong Zhang, Junbin Zhang, Jinxiang Zhang, Qingde Wang* & Timothy R. Billiar*. ADAR1 Suppresses the Activation of Cytosolic RNA-Sensing Signaling Pathways to Protect the Liver from Ischemia/Reperfusion Injury. Scientific Reports, 2016, 6:20248|DOI: 10.1038/srep20248.
7.	Hui Wang#, Haojun Shi, Jing Zhang, Guoliang Wang, Jinxiang Zhang, Fagang Jiang, and Qing Xiao*. Toll-Like Receptor 4 in Bone Marrow-Derived Cells Contributes to the Progression of Diabetic Retinopathy. Mediators of Inflammation, 2014, 2014, Article ID 858763.
8.	Wang Hui#, Zhang Jinxiang*, Wu Heshui, Li Zhuoya, Zheng Qichang. Bone　marrow and non-bone marrow TLR4 regulates hepatic ischemia/reperfusion injury. Biochemical and Biophysical Research Communications, 2009, 389(2):328-332. 
9.	Zhang JinXiang#*, Wang Hui#, Xiao Qing, Liang HuiFang, Li ZhuoYa, Jiang ChunFang, Wu HeShui, Zheng QiChang. Hyaluronic Acid Fragments Evoke Kupffer Cells via TLR4 Signaling Pathway. Science in China Series C: Life Sciences, 2009, 52(2):147-154.
10.	Wang Hui#, Li Zhuoya, Wu Heshui, Wang Yang, Jiang Chunfang, Zheng Qichang and Zhang Jinxiang*. Endogenous danger signals trigger hepatic ischemia/reperfusion injury through toll-like receptor 4/nuclear factor-kappa B pathway. Chinese Medical Journal, 2007, 120(6):509-514.
11.	Wang Hui#，Zhang Jinxiang，Feng Wei，Zhang Shu，Liang Huifang，Wang Yang，Zheng Qichang，Li Zhuoya*. PIN1 gene overexpression and β-catenin gene mutation/expression in hepatocellular carcinoma and their significance. Journal of Huazhong University of Science and Technology (Med Sci), 2007, 27(1):54-57.
12.	Wang Hui#, Zhang Jinxiang*, Wu Heshui, Jiang Chunfang, Zheng Qichang, Li Zhuoya. Inhibition of RAW264.7 macrophage inflammatory cytokines release by small haparin RNAi targeting TLR4. Journal of Huazhong University of Science and Technology (Med Sci), 2006, 26(5):500-503.

Projects:
1.	ADAR1 limits RIG-I RNA-sensing pathways and suppresses IFN production to protect against liver ischemia and reperfusion injury, Natural Science Foundation of China, 2016-2019.
2.	TLR4 enhance the protection effect of BMSC against liver ischemia and reperfusion injury. Program Foundation of National Health and Family planning Commission of Hubei Province, 2013-2014.
3.	Adjustment of TLR4 on BMSC treatment effect against acute respiratory distress syndrome. Natural Science Foundation of Hubei Province, 2013-2014.
4.	Low molecular weight of Hyaluronic act as potential ligand to activate TLR4 to induce liver ischemia and reperfusion injury. Natural Science Foundation of China, 2008-2010.

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Hui WANG

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