Anbing SHI

Title: Professor

Department: Department of Biochemistry and Molecular Biology

Email: ashi@hust.edu.cn

Clinical Focus:

Research Focus/Interests: Our work focuses on genetic analysis of a fundamental event in membrane traffic, the formation of tubular membrane extensions from endosomes during receptor recycling. Recycling transport is essential for diverse biological processes, including cell signaling, cell migration, cytokinesis, and synaptic plasticity. Cargo carriers in the endosomal system are often tubular in nature, and the tubular shape has been proposed to help sort membrane intrinsic components away from the luminal content. The endocytic recycling compartment itself is composed of a dense collection of endosomal tubules and vesicles. In the C. elegans intestine, the basolateral recycling compartment enriched in clathrinid-independent cargo is highly tubular and appears to have many interconnections. Our previous work shows that the entire tubular network collapses upon loss of the small GTPase RAB-10, suggesting that this protein contributes to the formation and/or maintenance of such tubular endosomes. Currently, we are screening and characterizing newly identified RAB-10 regulators and effectors in vitro and in vivo. Our work will be of broad interest to the genetics and cell biology communities and provide a better understanding of the fundamental mechanisms of recycling transport. In addition, my lab set to identify the cellular components regulating extracellular vesicles biogenesis, with an emphasis on the poorly understood mechanism of targeting of intracellular proteins and RNAs to these vesicles in live animals, which is of fundamental importance to cancer biology and profoundly crucial in exploring therapeutical strategy per se.