Youming LU

Personal Information

Title: Professor

Department: Department of Pathophysiology

Email: lym@hust.edu.cn

Clinical Focus:

Research Focus/Interests: Neural circuits; Learning Memory & Synaptic plasticity; Cognitive disorders

Biography

Education

1981-1985              BSc in Medicine
Naval Medical College, Nanjing, China
1987-1990              MSc in Pharmacology
China Pharmaceutical University, Nanjing, China
1996-1999              PhD in Neuroscience
University of Toronto, Toronto, Canada

Boards, Advisory Committees, Professional Organizations

Director, Chinese Neuroscience Society
Executive Director, Chinese Association for Physiological Sciences
President, Hubei Association for Physiology
Vice President, Wuhan Medical Association

Publications

1.	Zhang T*., Ma S., Lv J., Wang X., Afewerky H. K., Li H#., Lu Y#. The emerging role of exosomes in Alzheimer's Disease. Aging research reviews 2021.
2.	Zheng K, Hu F, Zhou Y, Zhang J, Zheng J, Lai C, Xiong W, Cui K, Hu Y, Han Z, Zhang H, Chen J, Man H, Liu D, Lu Y*, Zhu LQ*. MiR-135a-5p mediates memory and synaptic impairments via the Rock2/Adducin1 signaling pathway in a mouse model of Alzheimer’s disease. Nature Communications 2021
3.	Xinyan Li#, Wenting Chen#, Quntao Yu, Qingping Zhang, Tongmei Zhang, Xian Huang, Hao Li, Aodi He, Hongyan Yu, Wei Jing, Huiyun Du, Xiao Ke, Bing Zhang, Qing Tian, Rong Liu, Youming Lu*. A circuit of mossy cells controls the efficacy of memory retrieval by Gria2I inhibition of Gria2. Cell reports 2021.
4.	Ma M, Xiong W, Hu F, Deng MF, Huang X, Chen JG, Man HY, Lu Y*, Liu D*, Zhu LQ*. A novel pathway regulates social hierarchy via lncRNA AtLAS and postsynaptic synapsin Iib. Cell Research 2020
5.	Zeyang Ji#, Hao Li#, Zhou Yang, Xian Huang, Xiao Ke, Sehui Ma, Zhijie Lin*, Youming Lu* and Mingjie Zhang*. Kibra Modulates Learning and Memory via Binding to Dendrin. Cell Reports 2019.
6.	Yu Guo#, Hao Li#, Xiao Ke, Manfei Deng, Zhuoze Wu, You Cai, Henok Kessete Afewerky, Xiaoan Zhang, Lei Pei, Youming Lu*. Degradation of Caytaxin Causes Learning and Memory Deficits via Activation of DAPK1 in Aging. Molecular Neurobiology 2018.
7.	Xinyan Li#, Wenting Chen#, Kai Pan#, Hao Li, Pei Pang, Yu Guo, Shu Shu, You Cai, Lei Pei, Dan Liu, Henok K.A, Qing Tian, Ling-Qiang Zhu* and Youming Lu*. Serotonin receptor 2c-expressing cells in the ventral CA1 control attention via innervation of the Edinger–Westphal nucleus. Nature Neuroscience 2018.
8.	Tongmei Zhang#, Pei Pang#, Zemin Fang#, Yu Guo, Hao Li, Xinyan Li, Tian Tian, Xin Yang, Wenting Chen, Shu Shu, Na Tang, Jianhua Wu, Houze Zhu, Lei Pei, Dan Liu, Qing Tian, Jian Wang, Lin Wang, Ling-Qiang Zhu, Youming Lu*. Expression of BC1 Impairs Spatial Learning and Memory in Alzheimer’s Disease Via APP Translation. Molecular Neurobiology 2018.
9.	Jinwei Zhu#, Qingqing Zhou#, Yuan Shang, Hao Li, Mengjuan Peng, Xiao Ke, Zhuangfeng Weng, Rongguang Zhang, Xuhui Huang, Shawn S.C. Li, Guoping Feng, Youming Lu and Mingjie Zhang*. Synaptic Targeting and Function of SAPAPs Mediated by Phosphorylation-Dependent Binding to PSD-95 MAGUKs. Cell Reports 2017.
10.	Houze Zhu#, Huanhuan Yan#, Na Tang#, Xinyan Li#, Pei Pang, Hao Li, Wenting Chen, Yu Guo, Shu Shu, You Cai, Lei Pei, Dan Liu, Min-Hua Luo, Hengye Man, Qing Tian, Yangling Mu, Ling-Qiang Zhu and Youming Lu*. Impairments of spatial memory in an Alzheimer’s disease model via degeneration of hippocampal cholinergic synapses. Nature Communications 2017.
11.	Shu Shu, Houze Zhu, Na Tang, Wenting Chen, Xinyan Li, Hao Li, Lei Pei,  Dan Liu, Yangling Mu, Qing Tian, Ling-Qiang Zhu and Youming Lu*.  Selective Degeneration of Entorhinal-CA1 Synapses in Alzheimer’s Disease via Activation of DAPK1. The Journal of Neuroscience 2016.
12.	Xin Yang#, Chengye Yao#, Tian Tian#, Xinyan Li#, Huanhuan Yan, Jianhua Wu, Hao Li, Lei Pei, Dan Liu, Qing Tian, Ling-Qiang Zhu and Youming Lu*. A novel mechanism of memory loss in Alzheimer’s disease mice via the degeneration of entorhinal–CA1 synapses. Molecular Psychiatry 2016.
13.	Yang Y., Shu X., Liu D., Shang Y., Wu Y., Pei L., Xu X., Tian Q., ZhangJ., Qian K., Wang Y.X., Petralia R.S., Tu W., Zhu L.Q., Wang J.Z., Lu Y. EPAC Null Mutation Impairs Learning and Social Interactions via Aberrant Regulation of miR-124 and Zif268 Translation. Neuron 2010.
14.	Tu, W., Xu, X., Peng, L., Zhong X., Zhang, W., Soundarapandian, M.M., Belal, C., Wang, M., Jia, N., Lew, F., Chan, S.L., Chen, Y., and Lu, Y. DAPK1 interaction with NMDA receptor NR2B subunits mediates brain damage in stroke. Cell Reports 2010.
15.	Kim D, Frank CL, Dobbin MM, Tsunemoto RK, Tu W, Peng PL, Guan JS, Lee BH, Moy LY, Giusti P, Broodie N, Mazitschek R, Delalle I, Haggarty SJ, Neve RL, Lu Y, Tsai LH.Deregulation of HDAC1 by p25/cdk5 in neurotoxicity. Neuron 2008.
16.	Peng, P.L., Zhong, X.F., Tu, W.H., Soundarapandian, M.M., Molner, P., Zhu, D.Y., Liu, S.H., and Lu, Y. ADAR2-Dependent RNA Editing of AMPA Receptor Subunit GluR2 Determines Vulnerability of Neurons in Forebrain Ischemia. Neuron 2006.
17.	Liu, S.H., Lau, L., Wei, J.S., Zhu, D.Y., Zou, S., Sun, H.S., Fu, Y.P., Liu, F., and Lu, Y.  Expression of Ca2+-permeable AMPA Receptor Channels Primes Cell Death in Transient Forebrain Ischemia. Neuron 2004.
18.	Zhu DY, Lau L, Liu SH, Wei JS, Lu Y. Activation of cAMP response element binding protein (CREB) after focal cerebral ischemia stimulates neurogenesis in the adult dentate gyrus. Proc. Natl. Acad. Sci. USA 2004.
19.	Wang J, Liu S, Fu Y, Wang JH, Lu Y. Cdk5 activation induces CA1 pyramidal cell death by direct phosphorylating NMDA receptors. Nature Neuroscience 2003.
20.	Lu, Y., Roder, J., Davidow, J., and Salter, M.W. Src activation in the induction of long-term potentiation in CA1 hippocampal neurons. Science 1998.

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Youming LU

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