Rong LIU

Personal Information

Title: Professor

Department: Department of Pathophysiology

Email: rong.liu@hust.edu.cn

Clinical Focus: Neurology

Research Focus/Interests: Pathogenesis, early diagnosis and prevention of Alzheimer’s disease and Depression

Biography

Professor Liu get her Ph.D. in Tongji Medical College, HUST, majoring in Pathophysiology. She is now an independent PI in Key Laboratory of Ministry of Education for Neurological Disorders, China; the outstanding scholar awarded by Hubei Natural  Science Foundation; and members of several academic associations such as Chinese Association of Pathophysiology, Chinese Neuroscience Society and Hubei Society for Microcirculation. She is also a member of editorial board of several scientific journals such as Journal of Neurochemistry, Journal of Alzheimer Disease and Neuroscience Bulletin; the reviewer of more than twenty journals such as Cell reports, Theranostics, Journal of Neurochemistry, Hippocampus, Neuroscience Bulletin, etc; as well as the grant reviewer of National Natural Science Foundation of China and Medical Research Council of England.

As her research focuses on the pathogenesis of Alzheimer’s disease and Depression, Professor Liu has published more than 50 papers with an H-index 22. As a main leader, she was granted more than 5 projects by National Natural Science Foundation of China. She has guided 7 PhD students and 5 graduated students to get their degree and obtain positions in universities and high-level hospitals. Five of her students wined the National Scholarship for Graduate Student.

Education

2008   Ph.D. in Neuropathophysiology, Huazhong University of Science and Technology
2003   M.Sc. in Pathophysiology,  Huazhong University of Science and Technology
1999   M.D. in Clinical Medicine, Tongji Medical College

Boards, Advisory Committees, Professional Organizations

Member, Chinese Association of Pathophysiology (2001-present)
Member, Chinese Neuroscience Society (2005-present)
Member of Editorial Board, Journal of Neurochemistry
Member of Editorial Board, Journal of Alzheimer Disease
Member of Editorial Board, Neuroscience Bulletin

Publications

1.	Zhou Y, Yang D, Chen H, Zheng C, Jiang H, Liu X, Huang X, Ye S, Song S, Jiang N, Zhao Z, Ma S, Ma J, Huang K, Chen C, Fan X, Gong Y, Wang X, Fan J, Liu R*, Shentu Y*. Polyphyllin I attenuates cognitive impairments and reduces AD-like pathology through CIP2A-PP2A signaling pathway in 3XTg-AD mice. FASEB J. 2020 Dec;34(12):16414-16431.
2.	O'Connor M, Shentu YP, Wang G, Hu WT, Xu ZD, Wang XC, Liu R*, Man HY*. Acetylation of AMPA Receptors Regulates Receptor Trafficking and Rescues Memory Deficits in Alzheimer's Disease. iScience. 2020 Aug 15;23(9):101465. doi: 10.1016/j.isci.2020.101465. 
3.	Wei H, Zhang HL, Wang XC, Xie JZ, An DD, Wan L, Wang JZ, Zeng Y, Shu XJ, Westermarck J, Lu YM, Ohlmeyer M*, Liu R*. Direct Activation of Protein Phosphatase 2A (PP2A) by Tricyclic Sulfonamides Ameliorates Alzheimer's Disease Pathogenesis in Cell and Animal Models. Neurotherapeutics. 2020 Feb 24. doi: 10.1007/s13311-020-00841-6.
4.	Shentu YP, Hu WT, Zhang Q, Huo Y, Liang JW, Liuyang ZY, Zhou H, Wei H, Ke D,Wang XC, Wang JZ, Man HY, Westermarck J, Liu R*. CIP2A-promoted astrogliosis induces AD-like synaptic degeneration and cognitive deficits. Neurobiol Aging. 2019;75:198-208. 
5.	Shentu YP*, Hu WT, Liang JW, Liuyang ZY, Wei H, Qun W, Wang XC, Wang JZ, Westermarck J, Liu R*. Genistein Decreases APP/tau Phosphorylation and Ameliorates Aβ Overproduction Through Inhibiting CIP2A. Curr Alzheimer Res. 2019;16(8):732-740.
6.	Shentu YP, Huo Y, Feng XL, Gilbert J, Zhang Q, Liuyang ZY, Wang XL, Wang G, Zhou H, Wang XC, Wang JZ, Lu YM, Westermarck J, Man HY*, Liu R*. CIP2A Causes Tau/APP Phosphorylation, Synaptopathy, and Memory Deficits in Alzheimer's Disease. Cell Rep. 2018 Jul 17;24(3):713-723. doi: 10.1016/j.celrep.2018.06.009.（F1000Prime recommendation）
7.	Tuo QZ, Liuyang ZY, Lei P, Yan X, Shentu YP, Liang JW, Zhou H, Pei L, Xiong Y, Hou TY, Zhou XW, Wang Q, Wang JZ, Wang XC, Liu R*. Zinc induces CDK5 activation and neuronal death through CDK5-Tyr15 phosphorylation in ischemic stroke. Cell Death Dis. 2018 Aug 29;9(9):870. 
8.	Liang JW, Fang ZY, Huang Y, Liuyang ZY, Zhang XL, Wang JL, Hui W, Wang JZ, Wang XC, Zeng J*, Liu R*. Application of Weighted Gene Co-Expression Network Analysis to Explore the Key Genes in Alzheimer's Disease. J Alzheimers Dis. 2018 Aug 16. doi: 10.3233/JAD-180400.
9.	Zhou H, Guo Y, Li X, Liuyang ZY, Shentu YP, Jing XP, Liang JW, Zhou XW, Wang  XC, Wang JZ, Zeng J*, Liu R*. Long-term Helicobacter pylori Infection Does Not Induce Tauopathy and Memory Impairment in SD Rats. J Huazhong Univ Sci Technol［Med Sci］2017. 37(6):823-827. 
10.	Tuo QZ, Lei P*, Jackman KA, Li XL, Xiong H, Li XL, Liuyang ZY, Roisman L, Zhang ST, Ayton S, Wang Q, Crouch PJ, Ganio K, Wang XC, Pei L, Adlard PA, Lu YM, Cappai R, Wang JZ, Liu R*, Bush AI*. Tau-mediated iron export prevents ferroptotic damage after ischemic stroke. Mol Psychiatry. 2017 Nov;22(11):1520-1530. doi:10.1038/mp.2017.171. (ESI  Highly Cited Paper)
11.	Qiu M, Shentu YP, Zeng J, Wang XC, Yan X, Zhou XW, Jing XP, Wang Q, Man HY, Wang JZ, Liu R*. Zinc mediates the neuronal activity-dependent anti-apoptotic effect. PLoS One. 2017;12(8):e0182150. 
12.	Sun XY, Tuo QZ, Liuyang ZY, Xie AJ, Feng XL, Yan X, Qiu M, Li S, Wang XL, Cao FY, Wang XC, Wang JZ*, Liu R*. Extrasynaptic NMDA receptor-induced tau overexpression mediates neuronal death through suppressing survival signaling ERK phosphorylation. Cell Death Dis. 2016 Nov 3;7(11):e2449. 
13.	Xiong Y, Luo DJ, Wang XL, Qiu M, Yang Y, Yan X, Wang JZ, Ye QF, Liu R*. Zinc binds to and directly inhibits protein phosphatase 2A in vitro. Neurosci Bull.2015 Jun;31(3):331-7. 
14.	Wang XL, Xiong Y, Yang Y, Tuo QZ, Wang XC, Chen R, Tian Q, Zhang ZP, Yan X, Yang ZY, Wang JZ*, Liu R*. A novel tacrine-dihydropyridine hybrid (-)SCR1693 induces tau dephosphorylation and inhibits Aβ generation in cells. European Journal of Pharmacology. 2015, 754: 134-139  
15.	Wang XL, Zeng J, Yang Y, Xiong Y, Zhang ZH, Qiu M, Yan X, Sun XY, Tuo QZ, Liu R*, Wang JZ*. Helicobacter pylori filtrate induces Alzheimer-like tau hyperphosphorylation by activating glycogen synthase kinase-3β. J Alzheimers Dis. 2015;43(1):153-65. 
16.	Wang XL, Zeng J, Feng J, Tian YT, Liu YJ, Qiu M, Yan X, Yang Y, Xiong Y, Zhang ZH, Wang Q, Wang JZ*, Liu R*. Helicobacter pylori filtrate impairs spacial learning and memory in rat and increases β-amyloid by enhancing expression of presenilin-2. Frontiers in Aging Neuroscience, 11 April 2014 | doi: 10.3389/fnagi.2014.00066 
17.	Yang Y, Jing XP, Zhang SP, Gu RX, Tang FX, Wang XL, Xiong Y, Qiu M, Sun XY, Ke D, Wang JZ, Liu R*. High dose zinc supplementation induces hippocampal zinc deficiency and memory impairment with inhibition of BDNF signaling. PLoS One. 2013;8(1):e55384.
18.	Xiong Y, Jing XP, Zhou XW, Wang XL, Yang Y, Sun XY, Qiu M, Cao FY, Lu YM, Liu R*, Wang JZ*. Zinc induces protein phosphatase 2A inactivation and tau hyperphosphorylation through Src dependent PP2A (tyrosine 307) phosphorylation. Neurobiol Aging. 2013 Mar;34(3):745-56. 
19.	Sun XY, Wei YP, Xiong Y, Wang XC, Xie AJ, Wang XL, Yang Y, Wang Q, Lu YM, Liu R*, Wang JZ. Synaptic released zinc promotes tau hyperphosphorylation by inhibition of PP2A. J Biol Chem.2012,287(14):11174-11182.

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Rong LIU

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