Chaohong LIU

Personal Information

Title: Professor

Department: Department of Pathogen Biology

Email: chaohongliu@hust.edu.cn

Clinical Focus:

Research Focus/Interests: 1. The pathogenesis of Wiskott Aldrich Syndrome 2. The coordination of BCR signaling and actin cytoskeleton during BCR activation 3. The development and function of regulatory T cells and iNKT 4. The dysregulation of BCR signaling in leukemia 5. The metabolism of lymphocytes 6. The immune dysregulation during virus infection such as SARS-COVID-2, Hepatitis virus and parasite invasion

Biography

Dr. Liu got his Ph.D. from University of Maryland, College Park. During his graduate study, he was mainly working on the regulatory functions of actin cytoskeleton in BCR signaling under the supervision of Dr. Wenxia Song. One of the important findings in his Ph.D. research is that N-WASP keeps B cell and autoimmunity in check. After finishing the Ph.D., he joined St.jude Children’s Research Hospital as a research fellow. He was working on the mTOR signaling in T cells in Dr. Hongbo Chi’s lab, who has made lots of groundbreaking discoveries on the role of mTOR signaling in T cell metabolism. During his research career, he has published 20 papers as the first-author and corresponding-author papers, such as Blood, JACI, Science Advances, Leukemia, Plos Biology, Blood Advances, journal of Immunology, and co-authored 24 papers, such as Immunity, Journal of Experimental Medicine and Cell report. He is the associate editor for Journal of Clinical and Translational Hepatology and also the reviewer for several journals such as Signal transduction and targeted therapy and Experimental hematology.

Education

2013   PhD in Cell Biology and Molecular Genetics, University of Maryland, College Park
2006   MS in Biochemistry and Molecular Biology, Wuhan Institute of Virology, Chinese Academy of Science
2003   BS in Biotechnology, Wuhan University

Boards, Advisory Committees, Professional Organizations

Member, American Society of Immunology
Member, Chinese Society of Hematology
Member, Chinese Society of Immunology

Publications

1.	Yang L, Li N, Yang D, Chen A, Tang J, Jing Y, Kang D, Jiang P, Dai X, Luo L, Chen Q, Chang J, Liu J, Gu H, Huang Y, Chen Q, Li Z, Zhu Y, Miller H, Chen Y, Qiu L, Mei H, Hu Y, Gong Q, Liu C*. CCL2 regulation of MST1-mTOR-STAT1 signaling axis controls BCR signaling and B-cell differentiation. Cell Death and Differentiation. 2021 Apr 20.doi:10.1038/s41418-021-00775-2. Online ahead of print. IF=10.717
2.	Chen Y#,Chen Y#,Yin W#, Han H, Miller H, Li J, Herrada A, Kubo M, Sui Z*, Gong Q*, Liu C*.The regulation of DOCK family proteins on T and B cells. J Leukoc Biol. 2021 Feb;109(2):383-394. *Co-corresponding author. IF=3.757   
3.	Du Z#, Chen A#, Huang L, Dai X, Chen Q, Yang D, Li L, Miller H, Westerberg L, Ding Y, Tang X, Kubo M, Jiang L, Zhao X*, Wang H*, Liu C*. STAT3 couples with 14-3-3σ to regulate BCR signaling, B-cell differentiation, and IgE production. J Allergy Clin Immunol. 2020 Oct 9; S0091-6749(20)31403-2. Online ahead of print. IF=10.228
4.	Yang L, Jing Y, Kang D, Jiang P, Li N, Zhou X, Chen Y, Westerberg L, Liu C*. Ubiquitin-Specific Peptidase 18 Regulatesthe Differentiation and Function of Treg cells. Genes & diseases.2020.in Press. IF=4.803
5.	Wang L#, Jiang P#, Zhao S, Liu H, Liu L, Mor G, Liu C*, Liao A*. The dynamic profile and potential function of B-cell subsets during pregnancy. Cell Mol Immunol. 2020 Sep 2. doi: 10.1038/s41423-020-00535-1. Online ahead of print. IF=8.484
6.	Guo X, Wang C, Xu T, Yang L, Liu C, Qi X*. SiO2 prompts host defense against Acinetobacter baumannii infection by mTORC1 activation. Sci China Life Sci. 2020 Sep 1. doi: 10.1007/s11427-020-1781-8. Online ahead of print.
7.	Zhang T#, Sun J#, Cheng J#, Yin W, Li J, Miller H, Herrada AA, Gu H, Song H, Chen Y*, Gong Q*, Liu C*. The role of ubiquitinase in B cell development and function. J Leukoc Biol. 2020 Aug 20. doi: 10.1002/JLB.1MR0720-185RR. Online ahead of print. IF=3.757     
8.	Yang L#, Jing Y#, Wang W, Ying W, Lin L, Jiang C, Luo L, Kang D, Jiang P, Liu J, Chen Q, Miller H, Herrada A, Kubo M, Sun J*, Liu C* DOCK2 couples with LEF-1 to regulate B cell metabolism and memory response. Biochemical and Biophysical Research Communications. 2020 Aug 20;529(2):296-302. *Co-corresponding author. IF=2.985  
9.	Raynor JL, Liu C, Dhungana Y, Guy C, Chapman NM, Shi H, Neale G, Sesaki H, Chi H*. Hippo/Mst Signaling Coordinates Cellular Quiescence with Terminal Maturation in iNKT Cell Development and Fate Decisions. J Exp Med. 2020 Jun 1;217(6): e20191157.IF=11.743
10.	Record J#, Sendel A#, Kritikou J, Kuznetsov N, Brauner H, He M, Nagy N, Oliveira M, Griseti E, Haase C, Dahlström J,  Boddul S,  Wermeling F,  Thrasher A,  Liu C,  Andersson J,  Claesson H, Winqvist O,  Burns S,  Björkholm M,  Westerberg L*. An intronic deletion in megakaryoblastic leukemia 1 is associated with hyperproliferation of B cells in triplets with Hodgkin lymphoma. Haematologica. 2020 May;105(5):1339-1350. IF=7.116
11.	Jing Y#, Dai X#, Yang L#, Kang D, Jiang P, Li N, Cheng J, Li J, Miller H, Ren B, Gong Q, Yin W, Liu Z, Mattila P, Ning Q, Sun J, Yu B* and Liu C *.STING couples with PI3K to regulate actin reorganization during BCR activation. Science Advances. 2020 Apr 22; 6(17): eaax9455. *Co-corresponding author. IF=13.116  
12.	Du Z#, Yang D#, Zhang Y, Xuan X, Li H, Hu L, Ruan C, Li L, Chen A, Deng L, Chen Y, Xie J, Westerberg L, Huang L* and Liu C*. AKT2 deficiency impairs formation of the BCR signalosome. Cell Communication and Signaling. 2020 Apr 6;18(1):56. *Co-corresponding author. IF=4.344
13.	Lai Y#, Zhao A#, Tan M#, Yang M, Lin Y, Li S, Song J, Zheng H, Zhu Z, Liu D, Liu C, Li L* and Yang G*. DOCK5 regulates energy balance and hepatic insulin sensitivity by targeting mTORC1 signaling. EMBO Reports. 2020 Feb 5; 21 (2), e49473. IF=7.479
14.	Li N#, Jiang P#, Chen A, Luo X, Jing Y, Yang L, Kang D, Chen Q, Liu J, Chang J, Jellusova J, Miller H, Westerberg L, Wang CY, Gong Q*, Liu C*. CX3CR1 positively regulates BCR signaling coupled with cell metabolism via negatively controlling actin remodeling. Cellular and Molecular Life Sciences. 2020 Nov;77(21):4379-4395. *Co-corresponding author. IF=6.496   
15.	Zheng B, Zhang J, Chen H, Nie H, Miller H, Gong Q*, Liu C*. T Lymphocyte-Mediated Liver Immunopathology of Schistosomiasis. Frontiers in Immunology. 2020 Feb 18; 11:61. *Co-corresponding author. IF=5.085   
16.	Huang L, Sun X, Yang D, Dai X, Jiang P, Bai X, Zhang Y, Wang J, Li W, Miller H, Song W, Treanor B, Zhao X*, Liu C*. WASP and Mst1 coregulate B-cell development and B-cell receptor signaling. Blood Advances. 2020 Feb 11; 4 (3):573-585. *Co-corresponding author. IF=4.584   
17.	Jing Y#, Kang D#, Liu L, Huang H, Chen A, Yang L, Jiang P, Li N, Miller H, Liu Z, Zhu X, Yang J, Wang X, Sun J*, Liu Z*, Liu W*, Zhou X*, Liu C*. Dedicator of cytokinesis protein 2 couples with lymphoid enhancer-binding factor 1 to regulate expression of CD21 and B-cell differentiation. Journal of Allergy and Clinical Immunology. 2019 Nov; 144(5): p. 1377-1390 e4. *Co-corresponding author. IF=10.228  
18.	Xu C, Fang Y, Yang Z, Jing Y, Zhang Y, Liu C*, Liu W*. MARCKS Regulates Tonic and Chronic Active B Cell Receptor Signaling.Leukemia.2019 Mar; 33(3):710-729. *Co-corresponding author. IF=8.7
19.	Wang C, Ming B, Wu X, Wu T, Cai S, Hu P, Tang J, Tan Z, Liu C, Zhong J, Zheng F*, Dong L*. Sphingomyelin synthase 1 enhances BCR signaling to promote lupus-like autoimmune response. EBioMedicine. 2019 Jul; 45:578-587.IF=5.736
20.	Zhang J, Chen Q, Zhong J, Liu C, Zheng B*, Gong Q*.DPP-4 Inhibitors as Potential Candidates for Antihypertensive Therapy: Improving Vascular Inflammation and Assisting the Action of Traditional Antihypertensive Drugs. Frontiers in Immunology. 2019 May 9; 10:1050. IF=5.085
21.	Li J#, Yin W#, Jing Y, Kang D, Yang L, Cheng J, Yu Z, Peng Z, Li X, Wen Y, Sun X, Ren B*, Liu C*. The Coordination Between B Cell Receptor Signaling and the Actin Cytoskeleton During B Cell Activation. Frontiers in Immunology. 2019 Jan 9; 9:3096. *Co-corresponding author. IF=5.085  
22.	Cheng J#, Zhao L#, Zhang Y, Qin Y, Guan Y, Zhang T, Liu C, Zhou J*. Understanding the Mechanisms of Resistance to CAR T-Cell Therapy in Malignancies. Frontiers in Oncology. 2019 Nov 21; 9, 1237.IF=5.085
23.	Sun X#, Wei Y#, Lee PP, Ren B*, Liu C*. The role of WASp in T cells and B cells. Cellular Immunology. 2019 Jul; 341:103919. *Co-corresponding author. IF=4.078
24.	Chen A, Yang D, Xuan X, Miller H, Luo X, Yu J, Yang G, Wang H*, Liu C*. Dock5 controls the peripheral B cell differentiation via regulating BCR signaling and actin reorganization. Cellular Immunology. 2019 Mar; 337:15-21. *Co-corresponding author. IF=4.078   
25.	Shi H, Liu C, Tan H, Li Y, Nguyen TM, Dhungana Y, Guy C, Vogel P, Neale G, Rankin S, Feng Y, Peng J, Tao W*, Chi H*. Hippo Kinases Mst1 and Mst2 Sense and Amplify IL-2R–STAT5 Signaling in Regulatory T Cells to Establish Stable Regulatory Activity. Immunity. 2018 Nov 20; 49 (5): 899-914.e6. IF=21.522
26.	Zheng B, Xi Z, Liu R, Yin W, Sui Z, Ren B, Miller H, Gong Q*, Liu C*. The function of microRNAs in B cell development, lymphoma, and their potential in clinical practice. Frontiers in Immunology.2018. 2018 Apr 30; 9:936. *Co-corresponding author. IF=4.716   
27.	Sun X#, Wang J#, Qin T, Zhang Y, Huang L, Niu L, Bai X, Jing Y, Xuan X, Miller H, Zhao Y, Song W, Tang X, Zhang Z, Zhao X, Liu C*. Dock8 regulates BCR signaling and activation of memory B cells via WASP and CD19. Blood Advances. 2018 Feb 27; 2(4):401-413. IF=4.584  
28.	Cheng J, Jing Y, Kang D, Yang L, Li J, Yu Z, Peng Z, Li X, Wei Y, Gong Q, Miron RJ, Zhang Y, Liu C*. The Role of Mst1 in Lymphocyte homeostasis and function. Frontiers in Immunology. 2018 Feb 5; 9:149. IF=4.716  
29.	Huang L, Zhang Y, Xu C, Gu X, Niu L, Wang J, Sun X, Bai X, Xuan X, Li Q, Shi C, Yu B, Miller H, Yang G, Westerberg LS, Liu W, Song W, Zhao X*, Liu C*. Rictor positively regulates B cell receptor signaling by modulating actin reorganization via ezrin. PLos Biology. 2017 Aug 18; 15(8): e2001750. *Co-corresponding author. IF=9.163
30.	Yang M#, Wang J#, Wu S#, Yuan L, Zhao X, Liu C, Xie J, Jia Y, Lai Y, Zhao A, Boden G, Li L* and Yang G*. Duodenal GLP-1 signaling regulates hepatic glucose production through a PKC-δ-dependent neurocircuitry. Cell Death and Disease. 2017 Feb 9; 8 (2): e2609. IF=5.638  
31.	Li W#, Sun X#, Wang J#, Zhao Q, Dai R, Wang Y, Zhou L, Westerberg L, Ding Y*, Zhao X*, Liu C*. Defective thymic output in WAS patients is associated with abnormal actin organization. Scientific Reports. 2017 Sep 20; 7(1):11978. *Co-corresponding author. IF=4.122   
32.	Bai X, Huang L, Niu L, Zhang Y, Wang J, Sun X, Jiang H, Zhang Z, Miller H, Tao W, Zhou X, Zhao X, Liu C*. Mst1 positively regulates B cell receptor signaling via CD19 transcriptional levels. Blood Advances. 2016 Dec 14;1(3):219-230. IF=4.584 
33.	Bai X, Zhang Y, Huang L, Wang J, Li W, Niu L, Jiang H, Dai R, Zhou L, Zhang Z, Miller H, Song W, Zhao X, Liu C*. The early activation of memory B cells from Wiskott-Aldrich syndrome patients is suppressed by CD19 down regulation. Blood. 2016 Sep 29; 128(13):1723-34. IF=13.164
34.	Zhang X#, Dai R#, Li W, Zhao H, Zhang Y, Zhou L, Du H, Luo G, Wu J, Niu L, An Y, Zhang Z, Ding Y, Song W, Liu C*, Zhao X*. Abnormalities of follicular helper T-cell number and function in Wiskott-Aldrich syndrome. Blood. 2016 Jun 23; 127(25):3180-91. IF=13.164
35.	Liu C*, Richard K, Wiggins M, Zhu X, Conrad DH, Song W*.CD23 can negatively regulate B-cell receptor signaling. Scientific Reports. 2016 May 16; 6:25629. *Co-corresponding author. IF=4.259
36.	Bai X, Liu J, Zhang Z, Liu C, Zhang Y, Tang W, Dai R, Wu J, Tang X, Zhang Y, Ding Y, Jiang L, Zhao X*. Clinical, immunologic, and genetic characteristics of RAG mutations in 15 Chinese patients with SCID and Omenn syndrome. Immunologic Research. 2016 Apr; 64(2):497-507. IF=2.905
37.	Zhang Y, Cheng J, Liu C*. The unique role of the hepatitis virus B X protein on HEK 293 cell morphology and cellular change. Archives of Virology. 2016 May;161 (5), 1347-52. IF=2.058
38.	Qin T, An Y, Liu C, Wu J, Dai R, Liu D, Li X, Jiang L, Wu D, Tang X, Song W, Wang T*, Zhao X*. Novel DOCK8 gene mutations lead to absence of protein expression in patients with hyper-IgE syndrome. Immunologic Research. 2016 Feb; 64(1):260-71. IF=2.905
39.	Liu C, Chapman NM, Karmaus PW, Zeng H, Chi H*. mTOR and metabolic regulation of conventional and regulatory T cells. J Leukoc Biol. 2015 May; 97 (5), 837-847. IF=4.165
40.	Miao H#, Ou J#, Ma Y, Guo F, Yang Z, Wiggins M, Liu C, Song W, Han X, Wang M, Cao Q, Liang H, Xue B, Shi H, Gan L*, and Yu L*. Macrophage CGI-58 deficiency activates ROS-Inflammasome pathway to promote insulin resistance in mice. Cell Reports. 2014 Apr 10; 7(1):223-35. IF=7.207
41.	Song W*, Liu C, Upadhyaya A. The pivotal position of the actin cytoskeleton in the initiation and regulation of B cell receptor activation. Biochim Biophys Acta. 2014 Feb; 1838(2):569-78. IF=4.829
42.	Liu C *, Chen X*. Potential cellular host factor homologous to ZNF-136 can interact with truncated NS2 of HCV. Archives of Virology. 2014 Apr; 159(4):785-9. *Corresponding author. IF=2.39 Song W*, Liu C, Seeley-Fallen MK, Miller H, Ketchum C, Upadhyaya A. Actin-mediated feedback loops in B-cell receptor signaling. Immunological Reviews. 2013 Nov; 256(1):177-89. IF=12.909
43.	Liu C, Bai X, Wu J, Sharma S, Upadhyaya A, Dahlberg C, Westerberg L, Snapper S, Zhao X, Song W*. N-WASP is Essential for the Negative Regulation of B cell Receptor Signaling. Plos Biology. 2013 Nov; 11(11): e1001704. IF=11.771
44.	Liu C, Fallen M, Miller H, Upadhyaya A, Song W*. The actin cytoskeleton coordinates the signal transduction andantigen processing functions of the B cell antigen receptor. Front. Biol. 2013 Oct; 8(5):475-485.
45.	Arunkumar N#, Liu C#, Hang H, and Song W*. Toll-like receptor agonist induces apoptosis in mouse lymphoma B cells by altering NF-B activation. Cellular and Molecular Immunology. 2013 Jul;10(4):360-72. IF=4.185
46.	Liu C*, Wang Y, Wu C, Pei R, Song J, Chen S, Chen X*. Dioscin's antiviral effect in vitro. Virus Research. 2013 Mar; 172(1-2):9-14. * Corresponding author. IF=2.827
47.	Liu C, Miller H, Orlowski G, Hang H, Upadhyaya A, Song W*. Actin reorganization is required for the formation of polarized BCR signalosomes in response to both soluble and membrane-associated antigens. Journal of Immunology. 2012 Apr 1; 188(7):3237-46. IF=4.886
48.	Liu C*, Miller H, Sharma S, Beaven A, Upadhyaya A, Song W. Analyzing actin dynamics during the activation of the B cell receptor in live B cells. Biochem Biophys Res Commun. 2012 Oct 12; 427(1): 202-6. IF=2.985
49.	Becker-Herman S#, Meyer-Bahlburg A#, Schwartz M#, Jackson S, Hudkins K, Liu C, Sather B, Khim S, Liggitt D, Song W, Silverman G, Alpers C, Rawlings D*. WASp-deficient B cells play a critical, cell-intrinsic role in triggering autoimmunity. Journal of Experimental Medicine. 2011 Sep 26; 208(10):2033-42. IF=11.743
50.	Liu C, Miller H, Hui KL, Grooman B, Bolland S, Upadhyaya A, Song W*. A balance of Bruton's tyrosine kinase and SHIP activation regulates B cell receptor cluster formation by controlling actin remodeling. Journal of Immunology. 2011 Jul 1; 187(1):230-239. IF=4.886
51.	Cao J, Yu J, Liu C, Chen X, Liu S, Luo H, Yu H. Effects of hFRNK on E-cadherin/beta-catenin in colon cancer cells in vitro. Zhonghua Zhong Liu Za Zhi. 2007 May; 29(5):346-50. Chinese. 
52.	Cao J,Yu J, Liu C, Chen X, Luo H, Yu H. Effects of adenovirus vector expression hFRNK on phosphorylated 190RhoGAP and RhoA Activity in colo320WT colorectal cells. Chinese Journal of Practical Internal Medicine; 2007.8:581-584.
53.	Cao J, Sun T, Ding M, Chen Y, Liu C, Yu J, Yu H. Construction of inhibiting tumor cell motility and invasion murine FRNK recombinant adenovirus vector. Chinese Journal of Experimental Surgery; 2006.12:1502-1504. 
54.	Cao J#, Yu J#, Liu C#, Zhou L#, Yu H*. Effects of gastrin 17 on beta-catenin/Tcf-4 pathway in Colo320WT colon cancer cells. World J Gastroenterol. 2006 Dec 14; 12(46):7482-7. IF=3.665
55.	Liu C, Jiao C, Chen X. Cloning of HCV ns2 gene and its expression in prokaryotic and mammalian cells. Virologica Sinica 2006; 21(3):217-220. IF=0.553

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Chaohong LIU

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