Shengjun LU

Personal Information

Title: Associate Professor

Department: Department of Pathogen Biology

Email: lushengjun@hust.edu.cn

Clinical Focus:

Research Focus/Interests: 1. Parasitic Disease 2. NKG2D Based Immune Response 3. Type I Innate Lymphoid Cells Dr. Lu and his team are currently chasing mechanisms of NKG2DLs, especially their soluble forms participating in schistosomiasis induced hepatic fibrosis. Some genetic modified models including conditional knock-in models are handled and applied in our research. Besides, we are also interested in and doing some study on how ILC1 is involved in Schistosomiasis and other infectious disease.

Biography

1998-present    Assistant professor, Department of Pathogenic Biology, Huazhong University of Science and Technology
2011-2014   Postdoc Researcher, Department of Microbiology and Immunology, Medical University of South Carolina
2011              Postdoc Researcher, Department of Medicine, University of Washington

Education

1998   B.S., School of Life Science, Central China Normal University
2003   M.S., Department of Immunology, School of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology
2009   Ph.D., Department of Immunology, School of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology

Boards, Advisory Committees, Professional Organizations

Member, Chines Society of Immunology
Member, China Zoological Society
Member, Chinese Preventive Medicine Association –Young Researchers
Member, Hubei Preventive Medicine Association -Parasitology

Publications

1.	Xiao, J; Guan, F; & Sun, L; Zhang, Y;Zhang, X; #Lu, S; #Liu, W. 2020. B cells induced by Schistosoma japonicum infection display diverse regulatory phenotypes and modulate CD4+ T cell response. Parasites & vectors. 13(1):147. 10.1186/s13071-020-04015-3. 
2.	‡Lu S; ‡Chen J; Weng X; #Wu X; #Liang Z. 2019. Heterogeneity of antigen specificity between HLA-A*02:01 and other frequent Chinese HLA-A2 subtypes detected by a modified autologous lymphocyte-monocyte coculture. Molecular Immunology, 114: 389-394
3.	Lu S, Zhang J, Liu D, Li G, Staveley-O'Carroll KF, Li Z, #Wu JD. 2015. Nonblocking Monoclonal Antibody Targeting Soluble MIC Revamps Endogenous Innate and Adaptive Antitumor Responses and Eliminates Primary and Metastatic Tumors. Clin Cancer Res. Nov 1;21(21):4819-30.
4.	‡Lu S, ‡Liu G, ‡Wang X, Page ST, Higano CS, Plymate SR, Greenberg NM, Sun S, Li Z, #Wu JD. 2013. Perturbation of NK cell peripheral homeostasis accelerates prostate carcinoma metastasis. Journal of clinical investigation 123: 4410-22
5.	‡Lu S, ‡Weng X, Zhong M, Liang Z, Shen G, Chen J, #Wu X. 2009. Allo-restricted CTLs generated by coculturing of PBLs and autologous monocytes loaded with allogeneic peptide/HLA/IgG1-Fc fusion protein. Journal of leukocyte biology 85: 574-81
6.	Chen X, Yan Y, Lu S, Weng X, Liang Z, Li J, Zhong M, Tang J, Xiao W, Sun W, Shen G, #Wu X. 2009. Raising allo-restricted cytotoxic T lymphocytes by co-culture of murine splenocytes with autologous macrophage bearing the peptide/allo-major histococompatibility complex. Human immunology 70: 79-84
7.	Weng X, Zhong M, Liang Z, Lu S, Hao J, Chen X, Li J, Gong F, #Wu X. 2007. Peptide-dependent inhibition of alloreactive T-cell response by soluble divalent HLA-A2/IgG molecule in vitro. Transplantation 84: 1298-306
8.	Weng X, Liang Z, Lu X, Zhong M, Lu S, Zhang C, Deng J, #Wu X, Gong F. 2007. Peptide-specific, allogeneic T cell response in vitro induced by a self-peptide binding to HLA-A2. Science in China. Series C, Life sciences / Chinese Academy of Sciences 50: 203-11
9.	Lu S, Liang Z, Zhu H, #Wu X, Gong F. 2006. Generation and characterization of G11E5, a novel monoclonal antibody against HLA-G. Chinese Journal of Cellular and Molecular Immunology 22: 3

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Shengjun LU

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