Yisheng LU

Personal Information

Title: Professor

Department: Department of Physiology

Email: luys@hust.edu.cn

Clinical Focus:

Research Focus/Interests: to understand the neural circuit mechanisms of psychiatric disorders by using imaging and electrophysiological techniques.

Biography

Dr. Yisheng Lu is a neuroscientist and a professor at the Department of Physiology, Tongji Medical College (TJMC) of Huazhong University of Science and Technology (HUST). Before joining TJMC, he was a Postdoctoral fellow in Dr. Lin Mei’s lab at Georgia Regents University, USA. In Dr. Lin Mei’s lab, Dr. Lu and his colleagues identified neurotrophic factor neuregulin-1 and its receptor ErbB4 were critical for neurotransmitter GABA release, dysfunction of ErbB4 in parvalbumin-positive GABAergic interneurons could induce schizophrenia-like phenotypes. These findings were published in Neuron and PNAS. He also discovered LRP4 was required for neuromuscular junction maintenance, autoantibody of LRP4 in adult mice could induce myasthenia gravis. These findings were published in Journal of Clinical Investigation and Journal of Neuroscience. He got a Ph.D. degree in Biology in Dr. Yi Zhong’s lab at Tsinghua University, China. His research works were published in leading scientific journals, including Neuron, Journal of Clinical Investigation, PNAS, Journal of Neuroscience, Development, and FASEB Journal.

Education

2007   Tsinghua University, Ph. D. in Biology
1996   Huazhong Univ. of Science & Technology, B. S. in Biology

Boards, Advisory Committees, Professional Organizations

Member, Chinese Association of Physiological Sciences
Executive Council Member, The Physiology Association of Hubei Province
Executive Council Member, The Physiology Association of Wuhan

Publications

1.	Yandong Yi, Yuanlong Song, Yisheng Lu, Parvalbumin Interneuron Activation-Dependent Adult Hippocampal Neurogenesis Is Required for Treadmill Running to Reverse Schizophrenia-Like Phenotypes, Front Cell Dev Biol. 2020, 8(24): eCollection

2.	Ji H. So, Chao Huang, Minyan Ge, Guangyao Cai, Lanqiu Zhang, Yisheng Lu and Yangling Mu, Intense Exercise Promotes Adult Hippocampal Neurogenesis But Not Spatial Discrimination, Front Cell Neurosci. 2017, 11(13): eCollection

3.	Haitao Wu, Arnab Barik, Yisheng Lu, Chengyong Shen, Andrew Bowman, Lei Li, Anupama Sathyamurthy, Thiri W. Lin, Wen Cheng Xiong, Lin Mei, Slit2 as a β-catenin/ctnnb1-dependent retrograde signal for presynaptic differentiation, elife 2015, 4: e07266

4.	Yisheng Lu*, Xiangdong Sun*, Feng-Qing Hou, Lin-Lin Bi, Dong-Min Yin, Fang Liu, Yong-Jun Chen, Jonathan Bean, Hui-Feng Jiao, Xihui Liu, Bao-Ming Li, Wen-Cheng Xiong, Tian-Ming Gao and Lin Mei, Maintenance of GABAergic activity by neuregulin 1-ErbB4 in amygdala for fear memory, Neuron.2014, 84 (4): 835-846. (*: equal contribution)

5.	Lin-Lin Bi, Xiang-Dong Sun, Jie Zhang, Yi-Sheng Lu, Yi-Hua Chen, Jue Wang, Fang Liu, Meng Zhang, Fei Geng, Ji-Hong Liu, Lin Mei and Tian-Ming Gao, Amygdala NRG1-ErbB4 is critical for the modulation of anxiety-like behaviors, Neuropsychopharmacology. 2015, 40, 974–986

6.	Arnab Barik*, Yisheng Lu*, Anupama Sathyamurthy, Andrew Bowman, Chengyong Shen, Wen-cheng Xiong, Lin Mei, LRP4 is critical for neuromuscular junction maintenance, Journal of Neuroscience. 2014, 34 (42):13892-13905. (*: equal contribution)

7.	Chengyong Shen*, Yisheng Lu*, Bin Zhang*, Dwight Figueiredo‎, Haitao Wu, Barik Arnab, Wen-Cheng Xiong, Lin Mei, Antibodies against low-density lipoprotein receptor–related protein 4 induce myasthenia gravis, J. Clin. Invest. 2013, 123 (12), 5190-5202. (*: equal contribution)

8.	Dong-Min Yin*, Yong-Jun Chen*, Yi-Sheng Lu, Jonathan C Bean, Anupama Sathyamurthy, Chengyong Shen, Xihui Liu, Clifford Smith, Wen-Cheng Xiong and Lin Mei, Reversal of behavioral deficits and synaptic dysfunction in mice overexpressing neuregulin 1, Neuron. 2013, 78 (4), 644-657. (*: equal contribution)

9.	Haitao Wu, Yisheng Lu, Chengyong Shen, Neil Patel, Lin Gan, Wen C. Xiong, Lin Mei, Distinct Roles of Muscle and Motoneuron LRP4 in Neuromuscular Junction Formation, Neuron. 2012, 75 (1), 94-107.

10.	Haitao Wu*, Yisheng Lu*, Arnab Barik, Anish Joseph, Mark Makoto Taketo, Wen-Cheng Xiong, Lin Mei. β-Catenin gain of function in muscles impairs neuromuscular junction formation. Development. 2012, 139 (13), 2392-2404 (*: equal contribution).

11.	Yong-Jun Chen, Meng Zhang, Dong-Min Yin, Lei Wen, Annie Ting, Pu Wang, Yi-Sheng Lu, Xin-Hong Zhu, Shu-Ji Li, Cui-Ying Wu, Xue-Ming Wang, Cary Lai, Wen-Cheng Xiong, Lin Meia, Tian-Ming Gao. ErbB4 in parvalbumin-positive interneurons is critical for neuregulin 1 regulation of long-term potentiation. Proc. Natl. Acad. Sci. 2010, 107 (50), 21818-21823

12.	Lei Wen*, Yi-Sheng Lu*, Xin-Hong Zhu*, Xiao-Ming Li, Ran-Sook Woo, Yong-Jun Chen, Dong-Min Yin, Cary Lai, Alvin V. Terry Jr., Almira Vazdarjanova, Wen-Cheng Xiong, Lin Mei. Neuregulin 1 regulates pyramidal neuron activity via ErbB4 in parvalbumin-positive interneurons. Proc. Natl. Acad. Sci. 2010, 107 (3): 1211-1216 (*: equal contribution)

13.	Yisheng Lu*, Yubing Lv*, Yihong Ye, Yalin Wang, Yu Hong, Mark E. Fortini, Yi Zhong, Zuoping Xie. A role for presenilin in post stress regulation: Effects of presenilin mutations on Ca2+ currents in Drosophila, FASEB J. 2007, 21: 2368-2378 (*: equal contribution)

14.	Yubing Lu*, Yi-Sheng Lu*, Yichun Shuai, Chunhua Feng, Tim Tully, Zuoping Xie, Yizhong, Hai-Meng Zhou. The AKAP Yu is required for olfactory long-term memory formation in Drosophila, Proc. Natl. Acad. Sci. 2007, 104 (34): 13792-13797 (*: equal contribution)

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Yisheng LU

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