Jiong HU

Personal Information

Title: Professor

Department: Department of Histology and Embryology

Email: hujiong@hust.edu.cn

Clinical Focus:

Research Focus/Interests: Polyunsaturated fatty acid metabolism in angiogenesis, cardiomyocyte maturation, diabetic and age-related cardiovascular diseases

Biography

Working experience
04/2021 – current	Director of Department of Histology and Embryology, School of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology
11/2019 – current	Professor at Department of Histology and Embryology, School of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology
01/2017 – 11/2019	Junior group leader in Institute for Vascular Signalling, Centre for Molecular Medicine, Goethe-University, Frankfurt am Main, Germany
02/2018 – 11/2019	Y-DZHK representative, German Centre for Cardiovascular Research (DZHK) partner site RheinMain, Frankfurt am Main, Germany
01/2014 – 12/2016	Post-doctoral research fellow in Institute for Vascular Signalling, Centre for Molecular Medicine, Goethe-University, Frankfurt am Main, Germany


Professional Highlights
11/2018	Outstanding personality with migration background (Herausragende Persönlichkeit mit Migrationshintergrund), State of Frankfurt, Germany
06/2018	DR. PAUL UND CILLI WEILL-STIFTUNG, Frankfurt, Germany
04/2018	Oskar-Lapp-Forschungspreis from German Cardiac Society (Deutsche Gesellschaft für Kardiologie, DGK), Mannheim, Germany.
09/2015	Research Award, Global Ophthalmology awards program (GOAP) from Bayer.
10/2014	Hermann-Rein-Prize, German Society for Microcirculation and Vascular Biology (Gesellschaft für Mikrozirkulation und Vaskuläre Biologie, GfMVB), Münster, Germany.
04/2014	First Prize of Rudi-Busse Young Investigator Awards, German Cardiac Society (Deutsche Gesellschaft für Kardiologie, DGK), Mannheim, Germany.

Education

09/2008–12/2013   Goethe University, Frankfurt am Main, Germany.
PhD, Cardiovascular Physiology, Angiogenesis, Lymphangiogenesis, neuro-vascular coupling. 
Dissertation: “Role of the Soluble Epoxide Hydrolase in Angiogenesis and Retinopathy.” 
Supervised by Prof. Ingrid Fleming. Institute for Vascular Signaling, Centre for Molecular Medicine.

09/2001–06/2008   Tongji Medical College of Huazhong University of Science and Technology, Wuhan, China.
MScMed, Pharmacology, Clinical Pharmacology, Drug Metabolism. 
Thesis: “Effect of DDPH on Hepatic Drug Metabolizing Enzymes and Propafenone Pharmacokinetics in Rats.” 

06/2005   BSc, Medicinal Chemistry, Pharmaceutics, Department of Pharmacy.

Boards, Advisory Committees, Professional Organizations

Publications

1.	Wittig J, Drekolia MK, Kyselova A, Delgado Lagos F, Bochenek ML, Hu J, Schäfer K, Fleming I, Bibli SI. (2023) Endothelial-dependent S-Sulfhydration of tissue factor pathway inhibitor regulates blood coagulation. Redox Biol. 3;62:102694. doi: 10.1016/j.redox.2023.102694
2.	Li X, Kempf S, Günther S, Hu J, Fleming I. (2023) 11,12-EET Regulates PPAR-γ Expression to Modulate TGF-β-Mediated Macrophage Polarization. Cells. 12(5):700. doi: 10.3390/cells12050700
3.	Lopez M, Malacarne PF, Ramanujam DP, Warwick T, Müller N, Hu J, Dewenter M, Weigert A, Günther S, Gilsbach R, Engelhardt S, Brandes RP, Rezende F. (2022) Endothelial deletion of the cytochrome P450 reductase leads to cardiac remodelling. Front Physiol. 13:1056369. doi: 10.3389/fphys.2022.1056369
4.	Wu Y, Chen M, Chen Z, Shu J, Zhang L, Hu J, Yu H, Huang K, Liang M. Theaflavin-3,3'-Digallate from Black Tea Inhibits Neointima Formation Through Suppression of the PDGFRβ Pathway in Vascular Smooth Muscle Cells. (2022) Front Pharmacol. 13:861319. doi: 10.3389/fphar.2022.861319
5.	Tao X, Chen C, Chen Y, Zhang L, Hu J, Yu H, Liang M, Fu Q, Huang K. β2-adrenergic receptor promotes liver regeneration partially through crosstalk with c-met. (2022) Cell Death Dis. 13(6):571. doi: 10.1038/s41419-022-04998-0
6.	Chen Y, Lin J, Schlotterer A, Kurowski L, Hoffmann S, Hammad S, Dooley S, Buchholz M, Hu J, Fleming I, Hammes HP. (2021) MicroRNA-124 Alleviates Retinal Vasoregression via Regulating Microglial Polarization. Int J Mol Sci. 14;22(20):11068. doi: 10.3390/ijms222011068
7.	Hu J, Sisignano M, Brecht R, Perumal N, Angioni C, Bibli IS, Fisslthaler B, Kleinert H, Pfeiffer N, Fleming I, Manicam C. (2021) Cyp2c44 epoxygenase-derived epoxyeicosatrienoic acids in vascular smooth muscle cells elicit vasoconstriction of the murine ophthalmic artery. Sci Rep. 11(1):18764. doi: 10.1038/s41598-021-98236-w
8.	Wang B, Wu L, Chen J, Dong L, Chen C, Wen Z, Hu J, Fleming I, Wang DW. (2021) Metabolism pathways of arachidonic acids: mechanisms and potential therapeutic targets. Signal Transduct Target Ther. 6(1):94. doi: 10.1038/s41392-020-00443-w
9.	Zink J, Frye M, Frömel T, Carlantoni C, John D, Schreier D, Weigert A, Laban H, Salinas G, Stingl H, Günther L, Popp R, Hu J, Vanhollebeke B, Schmidt H, Acker-Palmer A, Renné T, Fleming I, Benz PM. (2021) EVL regulates VEGF receptor-2 internalization and signaling in developmental angiogenesis. EMBO Rep. 22(2):e48961. doi: 10.15252/embr.201948961
10.	Bibli SI, Hu J, Looso M, Weigert A, Ratiu C, Wittig J, Drekolia MK, Tombor L, Randriamboavonjy V, Leisegang MS, Goymann P, Delgado Lagos F, Fisslthaler B, Zukunft S, Kyselova A, Justo AFO, Heidler J, Tsilimigras D, Brandes RP, Dimmeler S, Papapetropoulos A, Knapp S, Offermanns S, Wittig I, Nishimura SL, Sigala F, Fleming I. (2021) Mapping the Endothelial Cell S-Sulfhydrome Highlights the Crucial Role of Integrin Sulfhydration in Vascular Function. Circulation. 143(9):935-948. doi: 10.1161/CIRCULATIONAHA.120.051877
11.	Lin J*, Hu J*, Schlotterer A, Wang J, Kolibabka M, Awwad K, Dietrich N, Breitschopf K, Wohlfart P, Kannt A, Lorenz K, Feng Y, Popp R, Hoffmann S, Fleming I, Hammes HP. (2020) Protective effect of soluble epoxide hydrolase inhibition in retinal vasculopathy associated with polycystic kidney disease. Theranostics 10(17): 7857-7871. doi: 10.7150/thno.43154 (*equal contribution)
12.	Wang S, Cao S, Arhatte M, Li D, Shi Y, Kurz S, Hu J, Wang L, Shao J, Atzberger A, Wang Z, Wang C, Zang W, Fleming I, Wettschureck N, Honoré E, Offermanns S. (2020) Adipocyte Piezo1 mediates obesogenic adipogenesis through the FGF1/FGFR1 signaling pathway in mice. Nat Commun. 11(1):2303. doi: 10.1038/s41467-020-16026-w
13.	Bibli SI, Hu J, Leisegang MS, Wittig J, Zukunft S, Kapasakalidi A, Fisslthaler B, Tsilimigras D, Zografos G, Filis K, Brandes RP, Papapetropoulos A, Sigala F, Fleming I. (2020) Shear stress regulates cystathionine γ lyase expression to preserve endothelial redox balance and reduce membrane lipid peroxidation. Redox Biol. 28:101379. doi: 10.1016/j.redox.2019.101379
14.	Hu J, Bibli SI, Wittig J, Zukunft S, Lin JH, Hammes H-P, Popp R, Fleming I. (2019) Soluble epoxide hydrolase promotes astrocyte survival in retinopathy of prematurity. J Clin Invest. 129(12):5204-5218. doi: 10.1172/JCI123835
15.	Leisegang MS, Bibli SI, Günther S, Pflüger-Müller B, Oo JA, Höper C, Seredinski S, Yekelchyk M, Schmitz-Rixen T, Schürmann C, Hu J, Looso M, Sigala F, Boon RA, Fleming I, Brandes RP. (2019) Pleiotropic effects of laminar flow and statins depend on the Krüppel-like factor-induced lncRNA MANTIS. Eur Heart J. 40(30):2523-2533. doi: 10.1093/eurheartj/ehz393
16.	Bibli SI*, Hu J*, Sigala F, Wittig I, Heidler J, Zukunft S, Tsilimigras D, Randriamboavonjy V, Wittig J, Kojonazarov B, Schürmann C, Siragusa M, Siuda D, Luck B, Malik RA, Filis K, Zografos G, Chen C, Wang DW, Pfeilschifter J, Brandes R, Szabo C, Papapetropoulos A, Fleming I. (2019) Cystathionine gamma lyase sulfhydrates the RNA binding protein HuR to preserve endothelial cell function and delay atherogenesis. Circulation. 139(1):101-114. doi: 10.1161/CIRCULATIONAHA.118.034757 (*equal contribution )
17.	Bibli SI, Luck B, Zukunft S, Wittig J, Chen W, Xian M, Papapetropoulos A, Hu J, Fleming I. (2018) A selective and sensitive method for quantification of endogenous polysulfide production in biological samples. Redox Biol. 18:295-304. doi: 10.1016/j.redox.2018.07.016
18.	Hitzel J, Lee E, Zhang Y, Bibli SI, Li X, Zukunft S, Pflüger B, Hu J, Schürmann C, Vasconez AE, Oo JA, Kratzer A, Kumar S, Rezende F, Josipovic I, Thomas D, Giral H, Schreiber Y, Geisslinger G, Fork C, Yang X, Sigala F, Romanoski CE, Kroll J, Jo H, Landmesser U, Lusis AJ, Namgaladze D, Fleming I, Leisegang MS, Zhu J, Brandes RP. (2018) Oxidized phospholipids regulate amino acid metabolism through MTHFD2 to facilitate nucleotide release in endothelial cells. Nat Commun. 12;9(1):2292. doi: 10.1038/s41467-018-04602-0
19.	Hu J, Frömel T, Fleming I. (2018) Angiogenesis and vascular stability in eicosanoids and cancer. Cancer Metastasis Rev. 37(2-3):425-438. doi: 10.1007/s10555-018-9732-2
20.	Hu J, Dziumbla S, Lin J, Bibli SI, Zukunft S, de Mos J, Awwad K, Froemel T, Jungmann A, Devraj K, Sodhi A, Eberhart CG, Fauser S, Cheng Z, Wang L, Hammock BD, Liebner S, Müller OJ, Glaubitz C, Hammes HP, Popp R, Fleming I. (2017) Inhibition of soluble epoxide hydrolase prevents diabetic retinopathy. Nature. 552(7684):248-252. doi: 10.1038/nature25013
21.	Hu J, Geyer A, Dziumbla S, Awwad K, Zeldin DC, Schunck W-H, Popp R, Frömel T, Fleming I. (2017) Role of Müller cell cytochrome P450 2c44 in murine retinal angiogenesis. Prostagland Other Lipid Mediat. 133:93-102. doi: 10.1016/j.prostaglandins.2017.04.002
22.	Leisegang MS, Fork C, Josipovic I, Richter FM, Preussner J, Hu J, Miller MJ, Epah J, Hofmann P, Gunther S, Moll F, Valasarajan C, Heidler J, Ponomareva Y, Freiman TM, Maegdefessel L, Plate KH, Mittelbronn M, Uchida S, Kunne C, Stellos K, Schermuly RT, Weissmann N, Devraj K, Wittig I, Boon RA, Dimmeler S, Pullamsetti SS, Looso M, Miller FJ, Brandes RP. (2017) Long noncoding RNA MANTIS facilitates endothelial angiogenic function. Circulation. 136(1):65-79. doi: 10.1161/CIRCULATIONAHA.116.026991
23.	Zhu Y*, Hu J*, He W, Gao X, Ren P, Chen H. (2016) DDPH, a novel antihypertensive agent, is a potential dual inhibitor of hepatic CYP2D and CYP3A. Chem Biol Interact. 247:55-63. doi: 10.1016/j.cbi.2016.01.019 (*equal contribution)
24.	Fork C, Gu L, Hitzel J, Josipovic I, Hu J, SzeKa Wong M, Ponomareva Y, Albert M, Schmitz SU, Uchida S, Fleming I, Helin K, Steinhilber D, Leisegang MS, Brandes, RP. (2015). Epigenetic Regulation of Angiogenesis by JARID1B-Induced Repression of HOXA5. Arterioscler Thromb Vasc Biol. 35(7):1645-52. doi: 10.1161/ATVBAHA.115.305561
25.	Elgheznawy A, Shi L, Hu J, Wittig I, Laban H, Pircher J, Mann AW, Provost P, Randriamboavonjy V, Fleming I. (2015) Dicer Cleavage by Calpain Determines Platelet microRNA Levels and Function in Diabetes. Circ Res. 117(2):157-65. doi: 10.1161/CIRCRESAHA.117.305784
26.	Geis T, Popp R, Hu J, Fleming I, Henke N, Dehne N, Brüne B. (2015) HIF-2α attenuates lymphangiogenesis by up-regulating IGFBP1 in hepatocellular carcinoma. Biol Cell. 107(6):175-88. doi: 10.1111/boc.201400079
27.	Awwad K, Hu J, Shi L, Mangels N, Abdel Malik R, Zippel N, Fisslthaler B, Eble JA, Pfeilschifter J, Popp R, Fleming I. (2015) Role of secreted modular calcium-binding protein 1 (SMOC1) in transforming growth factor β signalling and angiogenesis. Cardiovasc Res. 106(2):284-294. doi: 10.1093/cvr
28.	Hu J, Popp R, Frömel T, Ehling M, Awwad K, Adams RH., Hammes HP, Fleming I. (2014) Müller cells regulate Notch signalling and retinal angiogenesis via the soluble epoxide hydrolase-dependent generation of 19,20-dihydroxydocosapentaenoic acid. J Exp Med. 211(2):281-95. doi: 10.1084/jem.20131494
29.	Shi L, Fisslthaler B, Zippel N, Frömel T, Hu J, Elgheznawy A, Heide H, Popp R, Fleming I. (2013) MicroRNA-223 antagonizes angiogenesis by targeting β1 integrin and preventing growth factor signaling in endothelial cells. Circ Res. 113(12):1320-30. doi: 10.1161/CIRCRESAHA.113.301824
30.	Kovacevic I, Hu J, Siehoff-Icking A, Opitz N, Griffin A, Perkins AC, Munn AL, Müller-Esterl W, Popp R, Fleming I, Jungblut B, Hoffmeister M, Oess S. (2012) The F-BAR protein NOSTRIN participates in FGF signal transduction and vascular development. EMBO J. 31(15):3309-22. doi: 10.1038/emboj.2012.176
31.	Frömel T, Jungblut B, Hu J, Trouvain C, Barbosa-Sicard E, Popp R, Liebner S, Dimmeler S, Hammock BD, Fleming I. (2012) Soluble epoxide hydrolase regulates hematopoietic progenitor cell function via generation of fatty acid diols. Proc Natl Acad Sci USA. 109(25):9995-10000. doi: 10.1073/pnas.1206493109
32.	Müller H, Hu J, Popp R, Schmidt MH, Müller-Decker K, Mollenhauer J, Fisslthaler B, Eble JA, Fleming I. (2012) Deleted in malignant brain tumors 1 is present in the vascular extracellular matrix and promotes angiogenesis. Arterioscler Thromb Vasc Biol. 32(2):442-8. doi: 10.1161/ATVBAHA.111.239830
33.	Brecht K, Weigert A, Hu J, Popp R, Fisslthaler B, Korff T, Fleming I, Geisslinger G, Brüne B. (2011) Macrophages programmed by apoptotic cells promote angiogenesis via prostaglandin E2. FASEB J. 25(7):2408-17. doi: 10.1096/fj.10-179473
34.	Zhao L, Hu J, Chang Q, Ke Q, Xu R, Gu S, Chen H, Zeng F. (2008) A simple and sensitive HPLC method for quantitation of low phenoprolamine hydrochloride concentrations in human plasma and its pharmacokinetic application. Biomed Chromatogr. 22(3):333-338. doi: 10.1002/bmc.937

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Jiong HU

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