Xionglin FAN

Personal Information

Title: Professor

Department: Department of Pathogen Biology

Email: xlfan@hust.edu.cn

Clinical Focus:

Research Focus/Interests: 1. The interaction effects and mechanisms between major infectious disease pathogens such as Mycobacterium tuberculosis, new coronavirus, Helicobacter pylori, and hosts (cells, organs, individuals, and populations) 2. Anti-infection immunity 3. Development of new adjuvants and vaccines

Biography

07/2001-12/2004   Lecturer, Department of Microbiology, Fourth Military Medical University
01/2005-10/2009   Associate Professor, Department of Pathogen Biology, Tongji Medical College, Huazhong University of Science and Technology
07/2008-07/2009   Visiting scholar, Department of Molecular Microbiology and Immunology, Johns Hopkins University
11/2009-present   Professor, Department of Pathogen Biology, Tongji Medical College, Huazhong University of Science and Technology

Education

09/1995-07/1998   MD, Chongqing Medical University 
09/1998-07/2001   PhD, Fourth Military Medical University

Boards, Advisory Committees, Professional Organizations

Chairman, the Microbiology and Immunology Branch of the Hubei Medical Association
Member, Tropical Diseases and Parasitology Branch of Chinese Medical Association
Member, the Medical Microbiology and Immunology Branch of Chinese Microbiology Society

Publications

1.	Q. Lei, Y. Li, H. Hou, etal. Antibody dynamics to SARS-CoV-2 in asymptomatic COVID-19 infections. Allergy. 2021;76:551–561. (Co-corresponding author)
2.	Y.Li, M. Ma, Q.Lei, etal. Linear epitope landscape of SARS-CoV-2 Spike protein constructed from 1,051 COVID-19 patients. Cell reports, 2021,34(13): 108915. (Co-corresponding author)
3.	Y.Li, D. Lai, Q. Lei, etal. Systematic evaluation of SARS-CoV-2 spike protein derived peptides for diagnosis of COVID-19 patients. Cellular and Molecular Immunology, 2021,18:621-631. (Co-corresponding author)
4.	4.L.Hao, J. Ma, C. Shi, etal. Enhanced tuberculosis clearance through the combination treatment with recombinant adenovirus-mediated granulysin delivery. Theranostics, 2020, 10(22):10046-10056. (Corresponding author)
5.	L.Hao, Y. Wu, Y. Zhang, etal. Combinational PRR Agonists in Liposomal Adjuvant Enhances Immunogenicity and Protective Efficacy in a Tuberculosis Subunit Vaccine. Frontiers in Immunology, 2020, 11:575504. (Corresponding author)
6.	Y. Wu, M. Cai, J. Ma, etal. Heterologous Boost Following Mycobacterium bovis BCG Reduces the Late Persistent, Rather Than the Early Stage of Intranasal Tuberculosis Challenge Infection. Frontiers in Immunology, 2018, 9:2439. (Corresponding author)
7.	M. Tian, Z. Zhou, S. Tan, etal. Formulation in DDA-MPLA-TDB Liposome Enhances the Immunogenicity and Protective Efficacy of a DNA Vaccine against Mycobacterium tuberculosis Infection. Frontiers in Immunology, 2018, 9:310. (Corresponding Author)
8.	J. Ma, X. Teng, X. Wang, etal. A Multistage Subunit Vaccine Effectively Protects Mice Against Primary Progressive Tuberculosis, Latency and Reactivation. EBioMedicine, 2017, 22:143-154. (Corresponding author)
9.	Q. Yu, X. Wang, X. Fan. Adjuvant MTOM Mediates Mycobacterium tuberculosis Subunit Vaccine to Enhance Th1-Type T Cell Immune Responses and IL -2+ T Cells. Frontiers in Immunology, 2017, 8:585. (Corresponding author)

Projects:
1.	Research on a new plan for precise immune prevention and control of adult tuberculosis, 2018.1-2021.9, National Major program of Infectious Disease Prevention and Control from the Ministry of Science and Technology
2.	Knockout of the autophagy suppressor gene to enhance the protective efficacy and mechanism of BCG vaccine-mediated autophagy on tuberculosis, 2018.1-2021.12, National Natural Science Foundation of China
3.	IL-10 regulates the effect and mechanism of BCG vaccine prime-boosting strategy to prevent primary infection of Mycobacterium tuberculosis, 2020.1-2023.12, National Natural Science Foundation of China
4.	Development of a recombinant protein subunit vaccine against COVID-19, 2020.7-2022.12, Wuhan Bureau of Science and Technology

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Xionglin FAN

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