Qin FU

Personal Information

Title: Professor

Department: Department of Pharmacology

Email: fuqin@mails.tjmu.edu.cn

Clinical Focus: Heart failure, Diabetes

Research Focus/Interests: Cardiovascular Pharmacology; Molecular mechanisms underlying heart failure and diabetes complications

Biography

Education

2006   Huazhong University of Science and Technology, Ph.D. in Pharmacology
2002   Huazhong University of Science and Technology, M.S in Pharmacology
1998   Tongji Medical University, B.S in Clinical Medicine

Boards, Advisory Committees, Professional Organizations

Member, Cardiovascular Pharmacology Committee of Chinese Pharmacological Society
Member, Pharmacoepigenetic Committee of Chinese Pharmacological Society

Publications

1.	Xu R*, Gopireddy R*, Wu YD*, Wu L, Tao X, Shao J, Wang WX, Li L, Jovanovic A, Xu B, Kenyon N, Lu Q, Xiang YK#, Fu Q#. Hyperinsulinemia promotes heterologous desensitization of β2 adrenergic receptor in airway smooth muscle in obesity.  FASEB Journal. 2020 Mar;34(3):3996-4008 
2.	Tao X, Hu Y, Li L, Xu R, Fu J, Tong Q#, Fu Q#. Genetic deletion of β(2) adrenergic receptors exacerbates hepatocellular lipid accumulation in high-fat diet mice. BiochemBiophys Res Commun. 2019 Mar 26;511(1):73-78.
3.	Fu Q#, Wang Q#, Xiang YK# Insulin and β Adrenergic Receptor Signaling: Crosstalk in Heart. Trends Endocrinol Metab.  2017 Jun;28(6):416-427 
4.	Wang Q*, Liu Y*, Fu Q*, Xu B, Zhang Y, Kim S, Tan R, Barbagallo F, West T, Anderson E, Wei W, Abel ED#, Xiang YK#. Inhibiting Insulin-Mediated β2-Adrenergic Receptor Activation Prevents Diabetes-Associated Cardiac Dysfunction. Circulation. 2017 Jan 3;135(1):73-88.
5.	Fu Q*#, Kim S*, Soto D, De Arcangelis V, Dipilato L, Liu S, Xu B, Zhang J, Shi Q, Xiang YK#. A long-lasting β1 adrenergic receptor stimulation of cAMP/PKA signals in cardiac myocytes. J Biol Chem. 2014 May 23;289(21):14771-81
6.	Fu Q, Xu B, Liu Y, Parikh D, Li J, Li Y, Zhang Y, Riehle C, Zhu Y, Rawlings T, Shi Q, Clark RB, Chen X, Abel ED, Xiang YK. Insulin inhibits cardiac contractility by inducing a Gi-biased β2 adrenergic signaling in hearts. Diabetes. 2014 Aug;63(8):2676-89. 
7.	Fu Q#, Hu Y, Wang Q, Liu Y, Li N, Xu B, Kim S, Chiamvimonvat N, Xiang YK#. High-fat diet induces protein kinase A and G-protein receptor kinase phosphorylation of β (2) -adrenergic receptor and impairs cardiac adrenergic reserve in animal hearts. J Physiol. 2017 Mar 15;595(6):1973-1986.
8.	Fu Q, Shi Q, West TM, Xiang YK. Cross-talk between insulin signaling and GPCRs. J Cardiovasc Pharmacol. 2017 Aug;70(2):74-86.  
9.	Fu Q, Xiang YK. Trafficking of β-Adrenergic Receptors: implications in intracellular receptor signaling. Prog Mol Biol Transl Sci. 2015; 132:151-88
10.	Fu Q#, Xu B, Parikh D, Cervantes D, Xiang YK. Insulin induces IRS2-dependent and GRK2-mediated β2AR internalization to attenuate βAR signaling in cardiomyocytes. Cell Signal. 2015 Mar;27(3):707-15 
11.	Fu Q, Chen X, Xiang YK. Compartmentalization of β-adrenergic signals in cardiomyocytes. Trends Cardiovasc Med. 2013 Oct;23(7):250-6 
12.	Zhang Q, Xiang J, Wang X, Liu H, Hu B, Feng M, Fu Q#. Beta (2)-adrenoceptor agonist clenbuterol reduces infarct size and myocardial apoptosis after myocardial ischaemia/reperfusion in anaesthetized rats. Br J Pharmacol. 2010 160(6):1561-72. 
13.	Liu P, Xiang JZ, Zhao L, Yang L, Hu BR, Fu Q#. Effect of beta2-adrenergic agonist clenbuterol on ischemia/reperfusion injury in isolated rat hearts and cardiomyocyte apoptosis induced by hydrogen peroxide. Acta Pharmacol Sin. 2008 29(6):661-9. 
14.	Li JJ, Tang Q, Li Y, Hu BR, Ming ZY, Fu Q#, Qian JQ, Xiang JZ#. Role of oxidative stress in the apoptosis of hepatocellular carcinoma induced by combination of arsenic trioxide and ascorbic acid. Acta Pharmacol Sin. 2006 27(8):1078-84.

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Qin FU

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