Juan CHEN

Personal Information

Title: Professor

Department: Department of Biochemistry and Molecular Biology

Email: Chenjuanlinda69@163.com

Clinical Focus:

Research Focus/Interests: 1. Study on the mechanism of tau phosphorylation-induced axonal impairment in the pathogenesis of neurodegenerative diseases; 2. Study on the structure and function of membranous organelles and the pathogenesis of neurodegenerative diseases; 3. In view of the important role of neurodegenerative diseases the disease to explore the relevant drugs.

Biography

2011-present             Professor
Department of Biochemistry and Molecular Biology, Tongji Medical College, Huazhong University of Science and Technology (HUST)
2006-2008	         Visiting Scholar
Davis Heart & Lung Institute, Medical Center, Ohio State University
2006-2011	         Associate Professor
Department of Biochemistry and Molecular Biology, Tongji Medical College, HUST
2000-2006                Lecturer 
Department of Biochemistry and Molecular Biology, Tongji Medical College, HUST

Education

PhD in Biochemistry and Molecular Biology, 2004, Tongji Medical College, HUST, China.
MS in Biochemistry and Molecular Biology, 2000, Tongji Medical College, HUST, China.
BS in Clinic Medicine, 1996, Hubei Medical College, Wuhan University, China.

Boards, Advisory Committees, Professional Organizations

Publications

1.	Liang T, Xue F, Hang W, Wen B, Zhang Q, Chen J, Liu X, Chen J*. Neuron-Specific Apolipoprotein E4 (1-272) Fragment Induces Tau Hyperphosphorylation and Axonopathy via Triggering Endoplasmic Reticulum Stress. J Alzheimers Dis. 2019;71(2):597-611. 
2.	Hang W, He B, Chen J, Xia L, Wen B, Liang T, Wang X, Zhang Q, Wu Y, Chen Q, Chen J*. Berberine Ameliorates High Glucose-Induced Cardiomyocyte Injury via AMPK Signaling Activation to Stimulate Mitochondrial Biogenesis and Restore Autophagic Flux. Front Pharmacol. 2018 Oct 3;9:1121.
3.	Shi C, Zeng J, Li Z, Chen Q, Hang W, Xia L, Wu Y, Chen J*, Shi A. Melatonin Mitigates Kainic Acid-Induced Neuronal Tau Hyperphosphorylation and Memory Deficits through Alleviating ER Stress. Front Mol Neurosci. 2018 Jan 24;11:5
4.	Wang S, He B, Hang W, Wu N, Xia L, Wang X, Zhang Q, Zhou X, Feng Z, Chen Q, Chen J*. Berberine Alleviates Tau Hyperphosphorylation and Axonopathy-Associated with Diabetic Encephalopathy via Restoring PI3K/Akt/GSK3β Pathway. J Alzheimers Dis. 2018;65(4):1385-1400.
5.	Xue F, Shi C, Chen Q, Hang W, Xia L, Wu Y, Tao SZ, Zhou J, Shi A, Chen J*. Melatonin Mediates Protective Effects against Kainic Acid-Induced Neuronal Death through Safeguarding ER Stress and Mitochondrial Disturbance. Front Mol Neurosci. 2017 Feb 28;10:49. 
6.	Chen Q, Mo R, Wu N, Zou X, Shi C, Gong J, Li J, Fang K, Wang D, Yang D, Wang K, Chen J*. Berberine Ameliorates Diabetes-Associated Cognitive Decline through Modulation of Aberrant Inflammation Response and Insulin Signaling Pathway in DM Rats. Front Pharmacol. 2017 Jun 6;8:334. 
7.	Luo C, Shu Y, Luo J, Liu D, Huang DS, Han Y, Chen C, Li YC, Zou JM, Qin J, Wang Y, Li D, Wang SS, Zhang GM, Chen J*, Feng ZH*. Intracellular IL-37b interacts with Smad3 to suppress multiple signaling pathways and the metastatic phenotype of tumor cells. Oncogene. 2017 May 18;36(20):2889-2899.
8.	Tang L, Jiang L, Pan XD, Chen PP, Wang W, Jiao J, Yang Y, Chen J*, Wang LY. * Extremely severe aortic stenosis developed in a young female patient with underdiagnosis of homozygous familial hypercholesterolemia: An 8-year follow-up. Int J Cardiol. 2016 Mar 15;207:372-4.
9.	Xiao J, Duan Q, Wang Z, Yan W, Sun H, Xue P, Fan X, Zeng X, Chen J*, Shao C*, Zhu F*.Phosphorylation of TOPK at Y74, Y272 by Src increases the stability of TOPK and promotes tumorigenesis of colon. Oncotarget. 2016 Apr 26;7(17):24483-94.
10.	Liu X, Zhou J, Abid MD, Yan H, Huang H, Wan L, Feng Z, Chen J*. Berberine attenuates axonal transport impairment and axonopathy induced by Calyculin A in N2a cells. PLoS One. 2014 Apr 8;9(4):e93974.

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Juan CHEN

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