Xiaoqian CHEN

Personal Information

Title: Professor

Department: Department of Pathophysiology

Email: Chenxq@mails.tjmu.edu.cn

Clinical Focus:

Research Focus/Interests: Glioma; autism; stroke

Biography

Nov. 2007-present    Professor, Department of Pathophysiology, School of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
Nov. 2010-Nov. 2011   Postdoc/Visiting Scholar, Department of Pharmacology, Emory University, Atlanta, USA
Jun. 2004-Nov. 2007   Associate Professor, Department of Pathophysiology, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
Nov. 2002-Jun. 2004   Postdoc, Neuroscience Research Institute, Peking University & Department of Neurobiology, Peking University Health Science Center, Beijing, China 
Aug. 1997-Jan. 1999   Engineer, Laboratory of Molecular Virology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, China
Aug. 1988-Aug. 1994   Surgeon, Xi-Yuan Hospital, Chinese Academy of Traditional Chinese Medicine, Beijing, China

Education

2002   Ph.D., The Hong Kong University of Science and Technology, Hong Kong, China
Major: Biology
1997   Master in Medicine, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, China
Major: Immunology
1988   Bachelor in Medicine, Shanghai Medical University, Shanghai, China
Major: Immunology

Boards, Advisory Committees, Professional Organizations

Member, The Chinese Society of Neuroscience
Member, Hubei Society of Neuroscience
Executive Council Member, the Hubei Society of Pathophysiology

Publications

1.	Feng Liu, Xiaohong Xu, Chunyang Li, Chunyan Li, Yuanjun Li, Songlin Yin, Shangbin Yu, Xiao Qian Chen*(*, corresponding author). Mannose synergizes with chemoradiotherapy to cure cancer via metabolically targeting HIF-1 in a novel triple-negative glioblastoma mouse model. Clin Transl Med. 2020 Nov;10(7):e226. doi: 10.1002/ctm2.226. PMID: 33252849; PMCID: PMC7648968. 
2.	Ruo Qiao Chen#, Xiao Hong Xu#, Feng Liu, Chun Yang Li, Yuan Jun Li, Xiang Rui Li, Guo Yong Jiang, Feng Hu, Di Liu, Feng Pan, Xin Yao Qiu*, Xiao Qian Chen*.  The Binding of PD-L1 and Akt Facilitates Glioma Cell Invasion Upon Starvation via Akt/Autophagy/F-Actin Signaling. Front Oncol. 2019 Dec 3;9:1347. doi: 10.3389/fonc.2019.01347. PMID: 31850228; PMCID: PMC6901431. 
3.	Qian Zhang#, Dian Xing Hu#, Feng He, Chun Yang Li, Guang Jian Qi, Hong Wei Cai, Tong Xia Li, Jie Ming, Pei Zhang*, Xiao Qian Chen*, Bo Tian*. Locus coeruleus-CA1 projections are involved in chronic depressive stress-induced hippocampal vulnerability to transient global ischaemia. Nat Commun. 2019 Jul 3;10(1):2942. doi: 10.1038/s41467-019-10795-9. PMID: 31270312; PMCID: PMC6610150.
4.	Xiong XX#, Hu DX#, Xu L#, Lin H#, Zhang Y, Li CY,  Chen XQ*. Selective 14-3-3γ Upregulation Promotes Beclin-1-LC3-Autophagic Influx via β-Catenin Interaction in Starved Neurons In Vitro and In Vivo. Neurochem Res. 2019 Apr;44(4):849-858.
5.	Chen RQ, Liu F, Qiu XY*, Chen XQ*. The prognostic and therapeutic value of PD-L1 in glioma. Front Pharmacol. 2019 Jan 9;9:1503. 
6.	Qiu XY#, Hu DX#, Chen WQ, Chen RQ, Qian SR, Li CY, Li YJ, Xiong XX, Liu D, Pan F, Yu SB,  Chen XQ*. PD-L1 confers glioblastoma multiforme malignancy via Ras binding and Ras/Erk/EMT activation. Biochim Biophys Acta Mol Basis Dis.2018 Mar 3. 1864(5 Pt A):1754-1769. 
7.	Xiong XX#, Pan F#, Chen RQ, Hu DX, Qiu XY, Li CY, Xie XQ, Tian B, Chen XQ*. Neuroglobin boosts axon regeneration during ischemic reperfusion via p38 binding and activation depending on oxygen signal. Cell Death Dis. 2018 Feb 7;9(2):163. 
8.	Xie XQ#, Zhang P#, Tian B*, Chen XQ*. Downregulation of NAD-dependent deacetylase SIRT2 protects mouse brain against ischemic stroke. Mol Neurobiol 2017 Nov;54(9):7251-7261. 
9.	Liu D#, Qiu XY#, Wu X, Hu DX, Li CY, Yu SB, Pan F*, Chen XQ*. Piperlongumine suppresses bladder cancer invasion via inhibiting epithelial mesenchymal transition and F-actin reorganization. Biochem Biophys Res Commun. 2017 Dec 9;494(1-2):165-172. 
10.	Xiao ZX, Chen RQ, Hu DX, Xie XQ*, Yu SB*, Chen XQ*.  Identification of repaglinide as a therapeutic drug for glioblastoma multiforme.  Biochem Biophys Res Commun. 2017 Jun 17;488(1):33-39. 
11.	Xiong XX, Qiu XY, Hu DX, Chen XQ*. Advances in Hypoxia-mediated Mechanisms in Hepatocellular Carcinoma. Mol Pharmacol. 2017 Sep;92(3):246-255. 
12.	Chen Y, Liu JM, Xiong XX, Qiu XY, Pan F, Liu D, Lan SJ, Jin S, Yu SB, Chen XQ*. Piperlongumine selectively kills hepatocellular carcinoma cells and preferentially inhibits their invasion via ROS-ER-MAPKs-CHOP. Oncotarget. 2015 Mar 20; 6(8):6406-21. 
13.	Xiong XX#, Liu JM#, Qiu XY, Pan F, Yu SB, Chen XQ*. Piperlongumine induces apoptotic and autophagic death of the primary myeloid leukemia cells from patients via activation of ROS-p38/JNK pathways. Acta Pharmacol Sin. 2015 Mar; 36(3):362-74. 
14.	Liu QR, Liu JM, Chen Y, Xie XQ, Xiong XX, Qiu XY, Pan F, Liu D, Yu SB, Chen XQ*. Piperlongumine Inhibits Migration of Glioblastoma Cells via Activation of ROS-Dependent p38 and JNK Signaling Pathways. Oxid Med Cell Longev. 2014;2014:653732. 
15.	Qiu XY and  Chen XQ*. Neuroglobin: Recent Developments. Biomol Concepts 5(3): 195–208, 2014.
16.	XJ Lai, SQ Ye, L Zheng, L Li, QR Liu, SB Yu, Y Pang, S Jin, Q Li, ACH Yu, Chen XQ*. Selective 14-3-3γ induction quenches p-β-catenin Ser37/Bax-enhanced cell death in cerebral cortical neurons during ischemia. Cell Death Dis. 2014 Apr 17;5:e1184. 
17.	Li L, Liu QR, Xiong XX, Liu JM, Lai XJ, Cheng C, Pan F, Yu SB, Yu AC, Chen XQ*. Neuroglobin Promotes Neurite Outgrowth via Differential Binding to PTEN and Akt. Mol Neurobiol 49(1):149-62, 2014. 
18.	Liu JM#, Pan F#, Li L, Liu QR, Chen Y, Xiong XX, Cheng K, Yu SB, Shi Z, Yu AC, Chen XQ*. Piperlongumine selectively kills glioblastoma multiforme cells via reactive oxygen species accumulation dependent JNK and p38 activation. Biochem Biophys Res Commun 437(1): 87-93, 2013.
19.	Zhang J, Lan SJ, Liu QR, Liu JM, Chen XQ*. Neuroglobin, a Novel Intracellular Hexa-coordinated Globin, Functions as a Tumor Suppressor in Hepatocellular Carcinoma Via Raf/MAPK/Erk. Mol Pharmacol 83(3): 1-11, 2013.)
20.	Ye SQ#, Zhou XY#, Lai XJ, Zheng L, Chen XQ*. Silencing neuroglobin enhances neuronal vulnerability to oxidative injury by down-regulating 14-3-3γ. Acta Pharmacol Sin 30(7):913-8, 2009. 
21.	Li D, Chen XQ*, Li WJ, Yang YH, Wang JZ, Yu AC. Cytoglobin up-regulated by hydrogen peroxide plays a protective role in oxidative stress. Neurochem Res 32(8):1375-80. 2007.

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Xiaoqian CHEN

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